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• W2141143697 abstract "To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meningesOver a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (-4.54 +/- 1.12 log(10)/mL for daptomycin versus -3.43 +/- 1.17 log(10)/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was approximately 5% and approximately 2% into non-inflamed meninges.The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro." @default.
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• W2141143697 date "2006-04-01" @default.
• W2141143697 modified "2023-10-06" @default.
• W2141143697 title "Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis" @default.
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• W2141143697 doi "https://doi.org/10.1093/jac/dkl007" @default.
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