Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141150910> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2141150910 endingPage "349" @default.
- W2141150910 startingPage "344" @default.
- W2141150910 abstract "Background Overexpression of MCM 5 protein has been found to be significantly associated with the progression and prognosis of several human cancers. Methods This study used immunohistochemistry to examine the expression of MCM 5 protein in 97 specimens of oral squamous cell carcinomas ( OSCC ), 80 specimens of oral epithelial dysplasia ( OED , including 31 mild, 29 moderate, and 20 severe OED samples), and 20 specimens of normal oral mucosa ( NOM ). Results We found that the mean nuclear MCM 5 labeling indices ( LI s) increased significantly from NOM (15 ± 6%), through mild (25 ± 10%), moderate (34 ± 9%), and severe OED (43 ± 12%), to OSCC samples (61 ± 16%, P < 0.001). A significant correlation was found between the higher mean nuclear MCM 5 LI and OSCC s with site at the tongue ( P = 0.046), larger tumor size ( P = 0.032), positive lymph node metastasis ( P = 0.003), more advanced clinical stage ( P = 0.002), higher histological grade ( P = 0.002), deeper invasion depth ( P = 0.0001), and perineural invasion ( P = 0.0047). Only nuclear MCM 5 LI ≧ 60% was identified as independent unfavorable prognostic factor by multivariate regression analyses ( P = 0.049). The K aplan– M eier curve showed that patients with OSCC with a nuclear MCM 5 LI ≧ 60% had a significantly poorer cumulative survival than those with a nuclear MCM 5 LI < 60% (log‐rank test, P = 0.0062). Conclusions The increased expression of MCM 5 protein begins at the oral pre‐cancerous stage. The higher expression of MCM 5 protein is significantly associated with the aggressive progression and poor prognosis of OSCC ." @default.
- W2141150910 created "2016-06-24" @default.
- W2141150910 creator A5006615211 @default.
- W2141150910 creator A5008568890 @default.
- W2141150910 creator A5054820201 @default.
- W2141150910 creator A5056471376 @default.
- W2141150910 creator A5083649694 @default.
- W2141150910 creator A5084230915 @default.
- W2141150910 date "2013-11-18" @default.
- W2141150910 modified "2023-10-11" @default.
- W2141150910 title "Increased expression of MCM5 is significantly associated with aggressive progression and poor prognosis of oral squamous cell carcinoma" @default.
- W2141150910 cites W1856538661 @default.
- W2141150910 cites W1993516105 @default.
- W2141150910 cites W2002324408 @default.
- W2141150910 cites W2016081624 @default.
- W2141150910 cites W2023351261 @default.
- W2141150910 cites W2026694352 @default.
- W2141150910 cites W2038390682 @default.
- W2141150910 cites W2092022173 @default.
- W2141150910 cites W2105295214 @default.
- W2141150910 cites W2119325855 @default.
- W2141150910 cites W2126909443 @default.
- W2141150910 cites W2129756867 @default.
- W2141150910 cites W2129781454 @default.
- W2141150910 cites W2160780418 @default.
- W2141150910 cites W4376453612 @default.
- W2141150910 cites W3022268847 @default.
- W2141150910 doi "https://doi.org/10.1111/jop.12134" @default.
- W2141150910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24245508" @default.
- W2141150910 hasPublicationYear "2013" @default.
- W2141150910 type Work @default.
- W2141150910 sameAs 2141150910 @default.
- W2141150910 citedByCount "28" @default.
- W2141150910 countsByYear W21411509102015 @default.
- W2141150910 countsByYear W21411509102016 @default.
- W2141150910 countsByYear W21411509102017 @default.
- W2141150910 countsByYear W21411509102018 @default.
- W2141150910 countsByYear W21411509102019 @default.
- W2141150910 countsByYear W21411509102020 @default.
- W2141150910 countsByYear W21411509102021 @default.
- W2141150910 countsByYear W21411509102022 @default.
- W2141150910 countsByYear W21411509102023 @default.
- W2141150910 crossrefType "journal-article" @default.
- W2141150910 hasAuthorship W2141150910A5006615211 @default.
- W2141150910 hasAuthorship W2141150910A5008568890 @default.
- W2141150910 hasAuthorship W2141150910A5054820201 @default.
- W2141150910 hasAuthorship W2141150910A5056471376 @default.
- W2141150910 hasAuthorship W2141150910A5083649694 @default.
- W2141150910 hasAuthorship W2141150910A5084230915 @default.
- W2141150910 hasBestOaLocation W21411509101 @default.
- W2141150910 hasConcept C121608353 @default.
- W2141150910 hasConcept C126322002 @default.
- W2141150910 hasConcept C142724271 @default.
- W2141150910 hasConcept C146357865 @default.
- W2141150910 hasConcept C151730666 @default.
- W2141150910 hasConcept C204232928 @default.
- W2141150910 hasConcept C2777154038 @default.
- W2141150910 hasConcept C2779013556 @default.
- W2141150910 hasConcept C2779744641 @default.
- W2141150910 hasConcept C2781340805 @default.
- W2141150910 hasConcept C3019992690 @default.
- W2141150910 hasConcept C71924100 @default.
- W2141150910 hasConcept C86803240 @default.
- W2141150910 hasConcept C90924648 @default.
- W2141150910 hasConceptScore W2141150910C121608353 @default.
- W2141150910 hasConceptScore W2141150910C126322002 @default.
- W2141150910 hasConceptScore W2141150910C142724271 @default.
- W2141150910 hasConceptScore W2141150910C146357865 @default.
- W2141150910 hasConceptScore W2141150910C151730666 @default.
- W2141150910 hasConceptScore W2141150910C204232928 @default.
- W2141150910 hasConceptScore W2141150910C2777154038 @default.
- W2141150910 hasConceptScore W2141150910C2779013556 @default.
- W2141150910 hasConceptScore W2141150910C2779744641 @default.
- W2141150910 hasConceptScore W2141150910C2781340805 @default.
- W2141150910 hasConceptScore W2141150910C3019992690 @default.
- W2141150910 hasConceptScore W2141150910C71924100 @default.
- W2141150910 hasConceptScore W2141150910C86803240 @default.
- W2141150910 hasConceptScore W2141150910C90924648 @default.
- W2141150910 hasIssue "5" @default.
- W2141150910 hasLocation W21411509101 @default.
- W2141150910 hasLocation W21411509102 @default.
- W2141150910 hasOpenAccess W2141150910 @default.
- W2141150910 hasPrimaryLocation W21411509101 @default.
- W2141150910 hasRelatedWork W2365707941 @default.
- W2141150910 hasRelatedWork W2367950022 @default.
- W2141150910 hasRelatedWork W2794191114 @default.
- W2141150910 hasRelatedWork W2980367352 @default.
- W2141150910 hasRelatedWork W3024050243 @default.
- W2141150910 hasRelatedWork W3136794468 @default.
- W2141150910 hasRelatedWork W3141325065 @default.
- W2141150910 hasRelatedWork W4223578425 @default.
- W2141150910 hasRelatedWork W4225713342 @default.
- W2141150910 hasRelatedWork W4225777903 @default.
- W2141150910 hasVolume "43" @default.
- W2141150910 isParatext "false" @default.
- W2141150910 isRetracted "false" @default.
- W2141150910 magId "2141150910" @default.
- W2141150910 workType "article" @default.