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- W2141161267 abstract "The persistence of the defining characteristics of undifferentiated cells in vivo and in vitro is maintained via a complex interplay of several mechanisms, employing molecular events internal to the cell as well as signals originating outside the cell. The exogenous and the endogenous mechanisms maintaining stemness qualities of the cell are intricately interwoven with one another and susceptible to cross-interference. Mice and rats as animal models are almost universally considered to be close enough to humans so as to be used in research and applications eventually intended for use in human biology and medicine, at the same time being related distantly enough from primates so as not to overstep ethical boundaries. Studying the specific molecular features of both species in the context of maintenance of the undifferentiated state of mESC and hESC can provide researchers with an unique opportunity to unravel the network of interactions which take part in the decision about cell fate under different conditions; to glean interesting insights into the parallel evolution of the two species and to observe how different variants of basic cellular processes have been tried and tested in the evolutionary process. The present paper reviews the basic signalling pathways responsible for the maintenance of the undifferentiated state in mESC and hESC and analyses some specific aspects of the molecular physiology that are unique to the particular species." @default.
- W2141161267 created "2016-06-24" @default.
- W2141161267 creator A5011846754 @default.
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- W2141161267 date "2012-08-06" @default.
- W2141161267 modified "2023-10-05" @default.
- W2141161267 title "Of mice and men – differential mechanisms of maintaining the undifferentiated state in mESC and hESC" @default.
- W2141161267 cites W1608762409 @default.
- W2141161267 cites W1969401936 @default.
- W2141161267 cites W1970515701 @default.
- W2141161267 cites W1971476329 @default.
- W2141161267 cites W1972735741 @default.
- W2141161267 cites W1974509469 @default.
- W2141161267 cites W1975814452 @default.
- W2141161267 cites W1976878409 @default.
- W2141161267 cites W1977075613 @default.
- W2141161267 cites W1979245454 @default.
- W2141161267 cites W1979971207 @default.
- W2141161267 cites W1979981202 @default.
- W2141161267 cites W1981088384 @default.
- W2141161267 cites W1981557521 @default.
- W2141161267 cites W1983833034 @default.
- W2141161267 cites W1988294855 @default.
- W2141161267 cites W1990180850 @default.
- W2141161267 cites W1990183850 @default.
- W2141161267 cites W1991895828 @default.
- W2141161267 cites W1992160731 @default.
- W2141161267 cites W1992949513 @default.
- W2141161267 cites W1994109935 @default.
- W2141161267 cites W1997444723 @default.
- W2141161267 cites W1997506291 @default.
- W2141161267 cites W1999624225 @default.
- W2141161267 cites W2000246164 @default.
- W2141161267 cites W2006499356 @default.
- W2141161267 cites W2006650058 @default.
- W2141161267 cites W2014073178 @default.
- W2141161267 cites W2014385950 @default.
- W2141161267 cites W2015036988 @default.
- W2141161267 cites W2015974087 @default.
- W2141161267 cites W2018855387 @default.
- W2141161267 cites W2020484263 @default.
- W2141161267 cites W2020965347 @default.
- W2141161267 cites W2021317109 @default.
- W2141161267 cites W2022696353 @default.
- W2141161267 cites W2022978758 @default.
- W2141161267 cites W2033926629 @default.
- W2141161267 cites W2034931083 @default.
- W2141161267 cites W2038121225 @default.
- W2141161267 cites W2041019818 @default.
- W2141161267 cites W2042345702 @default.
- W2141161267 cites W2042637301 @default.
- W2141161267 cites W2049217916 @default.
- W2141161267 cites W2050632125 @default.
- W2141161267 cites W2050661185 @default.
- W2141161267 cites W2056089399 @default.
- W2141161267 cites W2056489392 @default.
- W2141161267 cites W2056590589 @default.
- W2141161267 cites W2057159461 @default.
- W2141161267 cites W2058521801 @default.
- W2141161267 cites W2059772934 @default.
- W2141161267 cites W2062254572 @default.
- W2141161267 cites W2065786458 @default.
- W2141161267 cites W2066337037 @default.
- W2141161267 cites W2073191701 @default.
- W2141161267 cites W2075827370 @default.
- W2141161267 cites W2075857997 @default.
- W2141161267 cites W2077264573 @default.
- W2141161267 cites W2085269742 @default.
- W2141161267 cites W2086253822 @default.
- W2141161267 cites W2086520553 @default.
- W2141161267 cites W2086943348 @default.
- W2141161267 cites W2088128367 @default.
- W2141161267 cites W2089426706 @default.
- W2141161267 cites W2091997664 @default.
- W2141161267 cites W2096592632 @default.
- W2141161267 cites W2105241566 @default.
- W2141161267 cites W2107085081 @default.
- W2141161267 cites W2107575419 @default.
- W2141161267 cites W2110559082 @default.
- W2141161267 cites W2111063080 @default.
- W2141161267 cites W2111778006 @default.
- W2141161267 cites W2116040284 @default.
- W2141161267 cites W2118959550 @default.
- W2141161267 cites W2119288897 @default.
- W2141161267 cites W2120138780 @default.
- W2141161267 cites W2125164793 @default.
- W2141161267 cites W2126851387 @default.
- W2141161267 cites W2127799088 @default.
- W2141161267 cites W2127953110 @default.
- W2141161267 cites W2134309794 @default.
- W2141161267 cites W2139697647 @default.
- W2141161267 cites W2141704910 @default.
- W2141161267 cites W2144526222 @default.
- W2141161267 cites W2146501296 @default.
- W2141161267 cites W2150727477 @default.
- W2141161267 cites W2154154942 @default.
- W2141161267 cites W2155507705 @default.