Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141189155> ?p ?o ?g. }
- W2141189155 endingPage "2285" @default.
- W2141189155 startingPage "2278" @default.
- W2141189155 abstract "Src family kinases (SFKs) are non-receptor tyrosine kinases that have been implicated as regulators of the inflammatory response. In this study, the role of SFK activation in the inflammatory response of macrophages to encephalomyocarditis virus (EMCV) infection was examined. Virus infection of macrophages stimulates the expression of cyclooxygenase-2 (COX-2), interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). Inhibition of SFK attenuates EMCV-induced COX-2 expression and prostaglandin E2 production, iNOS expression and subsequent nitric oxide production, and IL-1β expression. EMCV-induced COX-2 expression requires the activation of nuclear factor-κB and the mitogen-activated protein kinase p38. Consistent with these previous findings, inhibition of SFKs attenuated the phosphorylation of p38 in response to EMCV infection, suggesting that SFKs may act upstream of p38. These findings provide evidence that SFK activation plays an active role in the regulation of inflammatory gene expression by virus-infected macrophages." @default.
- W2141189155 created "2016-06-24" @default.
- W2141189155 creator A5007749593 @default.
- W2141189155 creator A5040859638 @default.
- W2141189155 creator A5046304077 @default.
- W2141189155 date "2010-05-26" @default.
- W2141189155 modified "2023-09-27" @default.
- W2141189155 title "Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages" @default.
- W2141189155 cites W1531606324 @default.
- W2141189155 cites W1851103272 @default.
- W2141189155 cites W1959189009 @default.
- W2141189155 cites W1963890587 @default.
- W2141189155 cites W1974630175 @default.
- W2141189155 cites W1990802251 @default.
- W2141189155 cites W1990915902 @default.
- W2141189155 cites W1996111909 @default.
- W2141189155 cites W2000693050 @default.
- W2141189155 cites W2005542209 @default.
- W2141189155 cites W2006944529 @default.
- W2141189155 cites W2013131507 @default.
- W2141189155 cites W2013937234 @default.
- W2141189155 cites W2023863771 @default.
- W2141189155 cites W2024091825 @default.
- W2141189155 cites W2031155523 @default.
- W2141189155 cites W2044079900 @default.
- W2141189155 cites W2049862010 @default.
- W2141189155 cites W2051152907 @default.
- W2141189155 cites W2055111778 @default.
- W2141189155 cites W2065554630 @default.
- W2141189155 cites W2084472569 @default.
- W2141189155 cites W2096204372 @default.
- W2141189155 cites W2101257013 @default.
- W2141189155 cites W2102928259 @default.
- W2141189155 cites W2114216755 @default.
- W2141189155 cites W2121369239 @default.
- W2141189155 cites W2126853519 @default.
- W2141189155 cites W2141137217 @default.
- W2141189155 cites W2149444093 @default.
- W2141189155 cites W2149826973 @default.
- W2141189155 cites W2154250655 @default.
- W2141189155 cites W2162841188 @default.
- W2141189155 cites W2338151820 @default.
- W2141189155 doi "https://doi.org/10.1099/vir.0.022665-0" @default.
- W2141189155 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3052521" @default.
- W2141189155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20505008" @default.
- W2141189155 hasPublicationYear "2010" @default.
- W2141189155 type Work @default.
- W2141189155 sameAs 2141189155 @default.
- W2141189155 citedByCount "10" @default.
- W2141189155 countsByYear W21411891552012 @default.
- W2141189155 countsByYear W21411891552013 @default.
- W2141189155 countsByYear W21411891552015 @default.
- W2141189155 countsByYear W21411891552018 @default.
- W2141189155 crossrefType "journal-article" @default.
- W2141189155 hasAuthorship W2141189155A5007749593 @default.
- W2141189155 hasAuthorship W2141189155A5040859638 @default.
- W2141189155 hasAuthorship W2141189155A5046304077 @default.
- W2141189155 hasBestOaLocation W21411891551 @default.
- W2141189155 hasConcept C108636557 @default.
- W2141189155 hasConcept C11960822 @default.
- W2141189155 hasConcept C132149769 @default.
- W2141189155 hasConcept C134018914 @default.
- W2141189155 hasConcept C159047783 @default.
- W2141189155 hasConcept C184235292 @default.
- W2141189155 hasConcept C2522874641 @default.
- W2141189155 hasConcept C2777622882 @default.
- W2141189155 hasConcept C42362537 @default.
- W2141189155 hasConcept C502942594 @default.
- W2141189155 hasConcept C51551487 @default.
- W2141189155 hasConcept C519581460 @default.
- W2141189155 hasConcept C62478195 @default.
- W2141189155 hasConcept C86803240 @default.
- W2141189155 hasConcept C95444343 @default.
- W2141189155 hasConcept C97029542 @default.
- W2141189155 hasConceptScore W2141189155C108636557 @default.
- W2141189155 hasConceptScore W2141189155C11960822 @default.
- W2141189155 hasConceptScore W2141189155C132149769 @default.
- W2141189155 hasConceptScore W2141189155C134018914 @default.
- W2141189155 hasConceptScore W2141189155C159047783 @default.
- W2141189155 hasConceptScore W2141189155C184235292 @default.
- W2141189155 hasConceptScore W2141189155C2522874641 @default.
- W2141189155 hasConceptScore W2141189155C2777622882 @default.
- W2141189155 hasConceptScore W2141189155C42362537 @default.
- W2141189155 hasConceptScore W2141189155C502942594 @default.
- W2141189155 hasConceptScore W2141189155C51551487 @default.
- W2141189155 hasConceptScore W2141189155C519581460 @default.
- W2141189155 hasConceptScore W2141189155C62478195 @default.
- W2141189155 hasConceptScore W2141189155C86803240 @default.
- W2141189155 hasConceptScore W2141189155C95444343 @default.
- W2141189155 hasConceptScore W2141189155C97029542 @default.
- W2141189155 hasIssue "9" @default.
- W2141189155 hasLocation W21411891551 @default.
- W2141189155 hasLocation W21411891552 @default.
- W2141189155 hasLocation W21411891553 @default.
- W2141189155 hasLocation W21411891554 @default.
- W2141189155 hasOpenAccess W2141189155 @default.
- W2141189155 hasPrimaryLocation W21411891551 @default.
- W2141189155 hasRelatedWork W1965506181 @default.