FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141202023> ?p ?o ?g. }

• W2141202023 endingPage "1450" @default.
• W2141202023 startingPage "1442" @default.
• W2141202023 abstract "The liver has enormous regenerative capacity such that, after partial hepatectomy, hepatocytes rapidly replicate to restore liver mass, thus providing a context for studying in vivo mechanisms of cell growth regulation. Bax inhibitor-1 (BI-1) is an evolutionarily conserved endoplasmic reticulum (ER) protein that suppresses cell death. Interestingly, the BI-1 protein has been shown to regulate Ca(2+) handling by the ER similar to antiapoptotic Bcl-2 family proteins. Effects on cell cycle entry by Bcl-2 family proteins have been described, prompting us to explore whether bi-1-deficient mice display alterations in the in vivo regulation of cell cycle entry using a model of liver regeneration. Accordingly, we compared bi-1(+/+) and bi-1(-/-) mice subjected to partial hepatectomy with respect to the kinetics of liver regeneration and molecular events associated with hepatocyte proliferation. We found that bi-1 deficiency accelerates liver regeneration after partial hepatectomy. Regenerating hepatocytes in bi-1(-/-) mice enter cell cycle faster, as documented by more rapid incorporation of deoxynucleotides, associated with earlier increases in cyclin D1, cyclin D3, cyclin-dependent kinase (Cdk) 2, and Cdk4 protein levels, more rapid hyperphosphorylation of retinoblastoma protein, and faster degradation of p27(Kip1). Dephosphorylation and nuclear translocation of nuclear factor of activated T cells 1 (NFAT1), a substrate of the Ca(2+)-sensitive phosphatase calcineurin, were also accelerated following partial hepatectomy in BI-1-deficient hepatocytes. These findings therefore reveal additional similarities between BI-1 and Bcl-2 family proteins, showing a role for BI-1 in regulating cell proliferation in vivo, in addition to its previously described actions as a regulator of cell survival." @default.
• W2141202023 created "2016-06-24" @default.
• W2141202023 creator A5002188124 @default.
• W2141202023 creator A5007084558 @default.
• W2141202023 creator A5008379933 @default.
• W2141202023 creator A5048228645 @default.
• W2141202023 creator A5058524912 @default.
• W2141202023 creator A5059438505 @default.
• W2141202023 creator A5080080264 @default.
• W2141202023 creator A5082603032 @default.
• W2141202023 creator A5091358858 @default.
• W2141202023 date "2007-02-15" @default.
• W2141202023 modified "2023-10-17" @default.
• W2141202023 title "Mice Lacking <i>bi-1</i> Gene Show Accelerated Liver Regeneration" @default.
• W2141202023 cites W1522731616 @default.
• W2141202023 cites W1522763255 @default.
• W2141202023 cites W1679452661 @default.
• W2141202023 cites W1923651867 @default.
• W2141202023 cites W1969836383 @default.
• W2141202023 cites W1980166477 @default.
• W2141202023 cites W1998492363 @default.
• W2141202023 cites W2004763695 @default.
• W2141202023 cites W2011863151 @default.
• W2141202023 cites W2021430023 @default.
• W2141202023 cites W2025421728 @default.
• W2141202023 cites W2032880746 @default.
• W2141202023 cites W2034277114 @default.
• W2141202023 cites W2041690669 @default.
• W2141202023 cites W2042165138 @default.
• W2141202023 cites W2043256229 @default.
• W2141202023 cites W2043493252 @default.
• W2141202023 cites W2045631311 @default.
• W2141202023 cites W2054820743 @default.
• W2141202023 cites W2055209830 @default.
• W2141202023 cites W2061948197 @default.
• W2141202023 cites W2064194904 @default.
• W2141202023 cites W2066099322 @default.
• W2141202023 cites W2066275626 @default.
• W2141202023 cites W2072482644 @default.
• W2141202023 cites W2080457496 @default.
• W2141202023 cites W2086090484 @default.
• W2141202023 cites W2086371845 @default.
• W2141202023 cites W2086595059 @default.
• W2141202023 cites W2101179323 @default.
• W2141202023 cites W2103061779 @default.
• W2141202023 cites W2105073777 @default.
• W2141202023 cites W2133795104 @default.
• W2141202023 cites W2140707292 @default.
• W2141202023 cites W2141000153 @default.
• W2141202023 cites W2148607448 @default.
• W2141202023 cites W2167870644 @default.
• W2141202023 cites W2171933068 @default.
• W2141202023 cites W2245791631 @default.
• W2141202023 cites W227887930 @default.
• W2141202023 cites W2319159316 @default.
• W2141202023 cites W29091496 @default.
• W2141202023 cites W4211173486 @default.
• W2141202023 cites W4237329722 @default.
• W2141202023 cites W43675158 @default.
• W2141202023 cites W96728624 @default.
• W2141202023 doi "https://doi.org/10.1158/0008-5472.can-06-0850" @default.
• W2141202023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17308082" @default.
• W2141202023 hasPublicationYear "2007" @default.
• W2141202023 type Work @default.
• W2141202023 sameAs 2141202023 @default.
• W2141202023 citedByCount "21" @default.
• W2141202023 countsByYear W21412020232012 @default.
• W2141202023 countsByYear W21412020232013 @default.
• W2141202023 countsByYear W21412020232014 @default.
• W2141202023 countsByYear W21412020232015 @default.
• W2141202023 countsByYear W21412020232017 @default.
• W2141202023 countsByYear W21412020232018 @default.
• W2141202023 countsByYear W21412020232020 @default.
• W2141202023 countsByYear W21412020232023 @default.
• W2141202023 crossrefType "journal-article" @default.
• W2141202023 hasAuthorship W2141202023A5002188124 @default.
• W2141202023 hasAuthorship W2141202023A5007084558 @default.
• W2141202023 hasAuthorship W2141202023A5008379933 @default.
• W2141202023 hasAuthorship W2141202023A5048228645 @default.
• W2141202023 hasAuthorship W2141202023A5058524912 @default.
• W2141202023 hasAuthorship W2141202023A5059438505 @default.
• W2141202023 hasAuthorship W2141202023A5080080264 @default.
• W2141202023 hasAuthorship W2141202023A5082603032 @default.
• W2141202023 hasAuthorship W2141202023A5091358858 @default.
• W2141202023 hasBestOaLocation W21412020231 @default.
• W2141202023 hasConcept C120089663 @default.
• W2141202023 hasConcept C124320809 @default.
• W2141202023 hasConcept C1491633281 @default.
• W2141202023 hasConcept C16438837 @default.
• W2141202023 hasConcept C171056886 @default.
• W2141202023 hasConcept C184235292 @default.
• W2141202023 hasConcept C199835354 @default.
• W2141202023 hasConcept C202751555 @default.
• W2141202023 hasConcept C2776062698 @default.
• W2141202023 hasConcept C2776200302 @default.
• W2141202023 hasConcept C2776795407 @default.
• W2141202023 hasConcept C2778198054 @default.
• W2141202023 hasConcept C2778298596 @default.

• next