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- W2141207013 abstract "Sympathetic activation in chronic renal failure (CRF) is a major mechanism leading to the progression of renal disease and hypertension. In the present study, we tested the hypothesis that in CRF increased reactive oxygen species (ROS) production in the RVLM mediated by enhanced circulating Angiotensin II (Ang II) is an important mechanism leading to hypertension in CRF. In CRF rats we found an increase in the abundance of p47 phox and gp91 phox mRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT 1 ) mRNA in the brainstem compared to controls (C). Tempol but not candesartan into the RVLM decreased MAP in CRF but not in C rats. GABA into the RVLM decreased MAP in CRF (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>63</mml:mn><mml:mo>±</mml:mo><mml:mn>8</mml:mn></mml:mrow></mml:math> mmHg) more intensely than in C (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>33</mml:mn><mml:mo>±</mml:mo><mml:mn>3</mml:mn></mml:mrow></mml:math> mmHg). The results suggest that increased oxidative stress within the RVLM has an important participation to maintain hypertension in CRF rats apparently independently of AT 1 Ang II receptors." @default.
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- W2141207013 date "2010-01-01" @default.
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- W2141207013 title "Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure" @default.
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- W2141207013 doi "https://doi.org/10.4061/2010/219358" @default.
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