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• W2141212433 endingPage "e1002740" @default.
• W2141212433 startingPage "e1002740" @default.
• W2141212433 abstract "In large populations, many beneficial mutations may be simultaneously available and may compete with one another, slowing adaptation. By finding the probability of fixation of a favorable allele in a simple model of a haploid sexual population, we find limits to the rate of adaptive substitution, , that depend on simple parameter combinations. When variance in fitness is low and linkage is loose, the baseline rate of substitution is , where is the population size, is the rate of beneficial mutations per genome, and is their mean selective advantage. Heritable variance in log fitness due to unlinked loci reduces by under polygamy and under monogamy. With a linear genetic map of length Morgans, interference is yet stronger. We use a scaling argument to show that the density of adaptive substitutions depends on , , , and only through the baseline density: . Under the approximation that the interference due to different sweeps adds up, we show that , implying that interference prevents the rate of adaptive substitution from exceeding one per centimorgan per 200 generations. Simulations and numerical calculations confirm the scaling argument and confirm the additive approximation for ; for higher , the rate of adaptation grows above , but only very slowly. We also consider the effect of sweeps on neutral diversity and show that, while even occasional sweeps can greatly reduce neutral diversity, this effect saturates as sweeps become more common—diversity can be maintained even in populations experiencing very strong interference. Our results indicate that for some organisms the rate of adaptive substitution may be primarily recombination-limited, depending only weakly on the mutation supply and the strength of selection." @default.
• W2141212433 created "2016-06-24" @default.
• W2141212433 creator A5011755952 @default.
• W2141212433 creator A5051861319 @default.
• W2141212433 date "2012-06-07" @default.
• W2141212433 modified "2023-09-29" @default.
• W2141212433 title "Limits to the Rate of Adaptive Substitution in Sexual Populations" @default.
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• W2141212433 doi "https://doi.org/10.1371/journal.pgen.1002740" @default.
• W2141212433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3369949" @default.
• W2141212433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22685419" @default.
• W2141212433 hasPublicationYear "2012" @default.

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