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• W2141229715 endingPage "5944" @default.
• W2141229715 startingPage "5937" @default.
• W2141229715 abstract "Genes for small heat shock proteins (hsp27 to hsp22) are activated in late third-instar larvae of Drosophila melanogaster in the absence of heat stress. This regulation has been simulated in cultured Drosophila cells in which the genes are activated by the addition of ecdysterone. Sequence elements (HERE) involved in ecdysterone regulation of the hsp27 and hsp23 genes have been defined by transfection studies and have recently been identified as binding sites for ecdysterone receptor. We report here that the hsp27 and hsp23 genes are regulated differently by ecdysterone. The hsp27 gene is activated rapidly by ecdysterone, even in the absence of protein synthesis. In contrast, high-level expression of the hsp23 gene begins only after a lag of about 6 h, is dependent on the continuous presence of ecdysterone, and is sensitive to low concentrations of protein synthesis inhibitors. Transfection experiments with reporter constructs show that this difference in regulation is at the transcriptional level. Synthetic hsp27 or hsp23 HERE sequences confer hsp27- or hsp23-type ecdysterone regulation on a basal promoter. These findings indicate that the hsp27 gene is a primary, and the hsp23 gene is mainly a secondary, hormone-responsive gene. Ecdysterone receptor is implied to play a role in the regulation of both genes." @default.
• W2141229715 created "2016-06-24" @default.
• W2141229715 creator A5024483127 @default.
• W2141229715 creator A5064228271 @default.
• W2141229715 creator A5078389409 @default.
• W2141229715 date "1991-12-01" @default.
• W2141229715 modified "2023-09-26" @default.
• W2141229715 title "Genes for Drosophila small heat shock proteins are regulated differently by ecdysterone." @default.
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• W2141229715 doi "https://doi.org/10.1128/mcb.11.12.5937" @default.
• W2141229715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/361747" @default.
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