FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141247906> ?p ?o ?g. }

• W2141247906 abstract "Some patients with epilepsy require treatment with >1 adjunctive antiepileptic drug (AED) to achieve adequate seizure remission. The purpose of this analysis was to evaluate the efficacy and safety of adding adjunctive pregabalin to an AED regimen that included levetiracetam in patients with refractory partial-onset epilepsy.Data from the pregabalin and placebo arms of two placebo-controlled, double-blind, randomized studies of pregabalin in patients who received adjunctive treatment with levetiracetam in addition to ≥1 other AEDs were pooled for this post hoc analysis. Patients (aged ≥18 years) had ≥4 partial-onset seizures and no 28-day period free of seizures during baseline. Efficacy outcomes included Response Ratio (RRatio), change from baseline in seizure frequency, proportion of patients with ≥50% reduction in seizure frequency, and 28-day seizure-freedom rate. Safety was evaluated using adverse events (AEs).In total, 138 patients were included in the analysis (placebo, n = 47; pregabalin, n = 91). Pregabalin was significantly better than placebo for difference in least squares mean of the RRatio (-16.4; 95% confidence interval [CI]: -28.5, -4.5; p = 0.0085), median of the difference in percentage change from baseline in seizure frequency (-22.3; 95% CI: -40.1, -7.2; p = 0.0095), and proportion of 50% responders (36.3 vs. 17.0; odds ratio, 3.2; 95% CI: 1.3, 8.3; p = 0.018), but not 28-day seizure-freedom rate (7 [7.7%] vs. 2 [4.3%]; p = 0.353). The most common AEs when adding pregabalin were dizziness/vertigo, fatigue, somnolence, blurred vision, and increased weight that were not proportional to the number of concomitant AEDs.In this population of patients with refractory partial-onset seizures, adding pregabalin to an AED regimen with levetiracetam produced further seizure reductions. The safety profile of pregabalin in patients receiving levetiracetam and ≥1 other AEDs did not appear to be compromised by the number of concomitant AEDs." @default.
• W2141247906 created "2016-06-24" @default.
• W2141247906 creator A5004662410 @default.
• W2141247906 creator A5020043337 @default.
• W2141247906 creator A5057725450 @default.
• W2141247906 creator A5070860360 @default.
• W2141247906 creator A5085960628 @default.
• W2141247906 date "2011-05-12" @default.
• W2141247906 modified "2023-10-03" @default.
• W2141247906 title "Pregabalin or placebo used adjunctively with levetiracetam in refractory partial-onset epilepsy: apost hocefficacy and safety analysis in combined clinical trials" @default.
• W2141247906 cites W105915516 @default.
• W2141247906 cites W12106092 @default.
• W2141247906 cites W1968626495 @default.
• W2141247906 cites W1974809694 @default.
• W2141247906 cites W1991097570 @default.
• W2141247906 cites W1997961150 @default.
• W2141247906 cites W2011456118 @default.
• W2141247906 cites W2012713607 @default.
• W2141247906 cites W2029610321 @default.
• W2141247906 cites W2041278632 @default.
• W2141247906 cites W2041426021 @default.
• W2141247906 cites W2049838912 @default.
• W2141247906 cites W2055427394 @default.
• W2141247906 cites W2057078791 @default.
• W2141247906 cites W2059212626 @default.
• W2141247906 cites W2072834684 @default.
• W2141247906 cites W2077603601 @default.
• W2141247906 cites W2078797427 @default.
• W2141247906 cites W2083785141 @default.
• W2141247906 cites W2090188920 @default.
• W2141247906 cites W2095780427 @default.
• W2141247906 cites W2098123454 @default.
• W2141247906 cites W2105359051 @default.
• W2141247906 cites W2116686895 @default.
• W2141247906 cites W2124847836 @default.
• W2141247906 cites W2162748306 @default.
• W2141247906 cites W2170826560 @default.
• W2141247906 cites W238201414 @default.
• W2141247906 cites W3188718543 @default.
• W2141247906 doi "https://doi.org/10.1185/03007995.2011.573778" @default.
• W2141247906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21561392" @default.
• W2141247906 hasPublicationYear "2011" @default.
• W2141247906 type Work @default.
• W2141247906 sameAs 2141247906 @default.
• W2141247906 citedByCount "0" @default.
• W2141247906 crossrefType "journal-article" @default.
• W2141247906 hasAuthorship W2141247906A5004662410 @default.
• W2141247906 hasAuthorship W2141247906A5020043337 @default.
• W2141247906 hasAuthorship W2141247906A5057725450 @default.
• W2141247906 hasAuthorship W2141247906A5070860360 @default.
• W2141247906 hasAuthorship W2141247906A5085960628 @default.
• W2141247906 hasConcept C118552586 @default.
• W2141247906 hasConcept C121332964 @default.
• W2141247906 hasConcept C126322002 @default.
• W2141247906 hasConcept C142424586 @default.
• W2141247906 hasConcept C142724271 @default.
• W2141247906 hasConcept C168563851 @default.
• W2141247906 hasConcept C197934379 @default.
• W2141247906 hasConcept C204787440 @default.
• W2141247906 hasConcept C27081682 @default.
• W2141247906 hasConcept C2776468701 @default.
• W2141247906 hasConcept C2777332695 @default.
• W2141247906 hasConcept C2778186239 @default.
• W2141247906 hasConcept C2781413609 @default.
• W2141247906 hasConcept C3018162438 @default.
• W2141247906 hasConcept C42219234 @default.
• W2141247906 hasConcept C535046627 @default.
• W2141247906 hasConcept C67761136 @default.
• W2141247906 hasConcept C71924100 @default.
• W2141247906 hasConcept C87355193 @default.
• W2141247906 hasConceptScore W2141247906C118552586 @default.
• W2141247906 hasConceptScore W2141247906C121332964 @default.
• W2141247906 hasConceptScore W2141247906C126322002 @default.
• W2141247906 hasConceptScore W2141247906C142424586 @default.
• W2141247906 hasConceptScore W2141247906C142724271 @default.
• W2141247906 hasConceptScore W2141247906C168563851 @default.
• W2141247906 hasConceptScore W2141247906C197934379 @default.
• W2141247906 hasConceptScore W2141247906C204787440 @default.
• W2141247906 hasConceptScore W2141247906C27081682 @default.
• W2141247906 hasConceptScore W2141247906C2776468701 @default.
• W2141247906 hasConceptScore W2141247906C2777332695 @default.
• W2141247906 hasConceptScore W2141247906C2778186239 @default.
• W2141247906 hasConceptScore W2141247906C2781413609 @default.
• W2141247906 hasConceptScore W2141247906C3018162438 @default.
• W2141247906 hasConceptScore W2141247906C42219234 @default.
• W2141247906 hasConceptScore W2141247906C535046627 @default.
• W2141247906 hasConceptScore W2141247906C67761136 @default.
• W2141247906 hasConceptScore W2141247906C71924100 @default.
• W2141247906 hasConceptScore W2141247906C87355193 @default.
• W2141247906 hasLocation W21412479061 @default.
• W2141247906 hasLocation W21412479062 @default.
• W2141247906 hasOpenAccess W2141247906 @default.
• W2141247906 hasPrimaryLocation W21412479061 @default.
• W2141247906 hasRelatedWork W144303070 @default.
• W2141247906 hasRelatedWork W1607945648 @default.
• W2141247906 hasRelatedWork W1975668205 @default.
• W2141247906 hasRelatedWork W1978781238 @default.
• W2141247906 hasRelatedWork W1993170193 @default.
• W2141247906 hasRelatedWork W2028236469 @default.
• W2141247906 hasRelatedWork W2041426021 @default.

• next