FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141266842> ?p ?o ?g. }

• W2141266842 endingPage "709" @default.
• W2141266842 startingPage "703" @default.
• W2141266842 abstract "The literature on non-esterified fatty acid (NEFA) concentrations in blood cell membranes from patients with multiple sclerosis (MS) is scarce and reports on concentrations in brain tissue from these patients are inconsistent. NEFAs are needed for several biological functions, for example, as precursors for inflammatory eicosanoid synthesis. The objective of this study was therefore to compare NEFA concentrations in blood cell membranes from patients with that of healthy control subjects, and to correlate possible changes with disease outcome. NEFA C18:2n-6 (9,12-octadecadienoic acid) was decreased in peripheral blood mononuclear cell membranes from patients, median (quartile range): patients: 0.05 (0.02) and controls: 0.07 (0.14) µg/mg protein, p = 0.007. C18:2n-6 also showed a weaker relationship with other fatty acids: with C16:0: patients: R = 0.40, p = 0.04; controls: R = 0.82, p = 0.000001. Saturated and MUFA showed positive correlations with the Bowel and bladder Functional System Scores (FSS). In contrast, in red blood cell membranes C18:2n-6 and C22:0 (docosanoic acid) showed inverse correlations with the Sensory and Brainstem FSS. The decrease in NEFA C18:2n-6 resulted in metabolic abnormalities between itself and saturated and monounsaturated NEFAs. Altered fatty acid composition in immune cell membranes would influence immune cell functions, and could possibly have contributed to the positive correlations between these fatty acids and disease outcome. Practical applications: Multiple sclerosis (MS) is a disease which presents with inflammation of the central nervous system. The cause of the disease is unknown and treatments such as anti-inflammatory, immunosuppressive medications, and fatty acids supplements are for the alleviation of symptoms only. The results from this study however, showed an altered relationship between polyunsaturated and saturated as well as monounsaturated non-esterified fatty acids in immune cells, which could have contributed to the inflammatory/infectious condition in these patients. The results from this study and further studies could possibly result in formulation of fatty acid supplements at correct doses or ratios for MS patients." @default.
• W2141266842 created "2016-06-24" @default.
• W2141266842 creator A5001334352 @default.
• W2141266842 creator A5029052856 @default.
• W2141266842 creator A5033148039 @default.
• W2141266842 creator A5037938673 @default.
• W2141266842 creator A5041928208 @default.
• W2141266842 creator A5061275899 @default.
• W2141266842 date "2012-03-21" @default.
• W2141266842 modified "2023-10-16" @default.
• W2141266842 title "Non-esterified fatty acids in blood cell membranes from patients with multiple sclerosis" @default.
• W2141266842 cites W1974682518 @default.
• W2141266842 cites W1984754901 @default.
• W2141266842 cites W1985625200 @default.
• W2141266842 cites W1991287825 @default.
• W2141266842 cites W1993833953 @default.
• W2141266842 cites W2001738533 @default.
• W2141266842 cites W2014460674 @default.
• W2141266842 cites W2020257525 @default.
• W2141266842 cites W2032140907 @default.
• W2141266842 cites W2044822083 @default.
• W2141266842 cites W2053962806 @default.
• W2141266842 cites W2068189851 @default.
• W2141266842 cites W2080408397 @default.
• W2141266842 cites W2083069281 @default.
• W2141266842 cites W2085800400 @default.
• W2141266842 cites W2088072138 @default.
• W2141266842 cites W2099483769 @default.
• W2141266842 cites W2112165124 @default.
• W2141266842 cites W2115183225 @default.
• W2141266842 cites W2120750905 @default.
• W2141266842 cites W2121048724 @default.
• W2141266842 cites W2126951750 @default.
• W2141266842 cites W2139437222 @default.
• W2141266842 cites W2140004057 @default.
• W2141266842 cites W2243074726 @default.
• W2141266842 cites W238671320 @default.
• W2141266842 cites W2438379048 @default.
• W2141266842 cites W4254794606 @default.
• W2141266842 doi "https://doi.org/10.1002/ejlt.201100216" @default.
• W2141266842 hasPublicationYear "2012" @default.
• W2141266842 type Work @default.
• W2141266842 sameAs 2141266842 @default.
• W2141266842 citedByCount "5" @default.
• W2141266842 countsByYear W21412668422013 @default.
• W2141266842 countsByYear W21412668422014 @default.
• W2141266842 countsByYear W21412668422016 @default.
• W2141266842 countsByYear W21412668422020 @default.
• W2141266842 crossrefType "journal-article" @default.
• W2141266842 hasAuthorship W2141266842A5001334352 @default.
• W2141266842 hasAuthorship W2141266842A5029052856 @default.
• W2141266842 hasAuthorship W2141266842A5033148039 @default.
• W2141266842 hasAuthorship W2141266842A5037938673 @default.
• W2141266842 hasAuthorship W2141266842A5041928208 @default.
• W2141266842 hasAuthorship W2141266842A5061275899 @default.
• W2141266842 hasConcept C126322002 @default.
• W2141266842 hasConcept C134018914 @default.
• W2141266842 hasConcept C137061746 @default.
• W2141266842 hasConcept C1491633281 @default.
• W2141266842 hasConcept C19038510 @default.
• W2141266842 hasConcept C202751555 @default.
• W2141266842 hasConcept C203014093 @default.
• W2141266842 hasConcept C2776557347 @default.
• W2141266842 hasConcept C2779772378 @default.
• W2141266842 hasConcept C2779979121 @default.
• W2141266842 hasConcept C2780640218 @default.
• W2141266842 hasConcept C41625074 @default.
• W2141266842 hasConcept C543025807 @default.
• W2141266842 hasConcept C55493867 @default.
• W2141266842 hasConcept C71924100 @default.
• W2141266842 hasConcept C86803240 @default.
• W2141266842 hasConcept C8891405 @default.
• W2141266842 hasConceptScore W2141266842C126322002 @default.
• W2141266842 hasConceptScore W2141266842C134018914 @default.
• W2141266842 hasConceptScore W2141266842C137061746 @default.
• W2141266842 hasConceptScore W2141266842C1491633281 @default.
• W2141266842 hasConceptScore W2141266842C19038510 @default.
• W2141266842 hasConceptScore W2141266842C202751555 @default.
• W2141266842 hasConceptScore W2141266842C203014093 @default.
• W2141266842 hasConceptScore W2141266842C2776557347 @default.
• W2141266842 hasConceptScore W2141266842C2779772378 @default.
• W2141266842 hasConceptScore W2141266842C2779979121 @default.
• W2141266842 hasConceptScore W2141266842C2780640218 @default.
• W2141266842 hasConceptScore W2141266842C41625074 @default.
• W2141266842 hasConceptScore W2141266842C543025807 @default.
• W2141266842 hasConceptScore W2141266842C55493867 @default.
• W2141266842 hasConceptScore W2141266842C71924100 @default.
• W2141266842 hasConceptScore W2141266842C86803240 @default.
• W2141266842 hasConceptScore W2141266842C8891405 @default.
• W2141266842 hasIssue "7" @default.
• W2141266842 hasLocation W21412668421 @default.
• W2141266842 hasOpenAccess W2141266842 @default.
• W2141266842 hasPrimaryLocation W21412668421 @default.
• W2141266842 hasRelatedWork W1527910795 @default.
• W2141266842 hasRelatedWork W1972134878 @default.
• W2141266842 hasRelatedWork W1980261828 @default.
• W2141266842 hasRelatedWork W1986052529 @default.
• W2141266842 hasRelatedWork W2069222261 @default.

• next