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• W2141290131 abstract "RNA interference (RNAi) mediated by small-interfering RNAs (siRNAs) is a highly effective gene-silencing mechanism with great potential for gene-therapeutic applications. siRNA agents also exert non-target-related biological effects and toxicities, including immune-system stimulation. Specifically, siRNA synthesized from the T7 RNA polymerase system triggers a potent induction of type-I interferon (IFN) in a variety of cells. Single-stranded RNA also stimulates innate cytokine responses in mammals. We found that pppGn (n = 2,3) associated with the 5′-end of the short-hairpin RNA (shRNA) from the T7 RNA polymerase system did not induce detectable amounts of IFN. The residual amount of guanine associated with the 5′-end and hairpin structures of the transcript was proportional to the reduction of the IFN response. Here we describe a T7 pppGn (n = 2,3) shRNA synthesis that does not induce the IFN response, and maintains the full efficacy of siRNA." @default.
• W2141290131 created "2016-06-24" @default.
• W2141290131 creator A5006470123 @default.
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• W2141290131 date "2007-11-21" @default.
• W2141290131 modified "2023-09-23" @default.
• W2141290131 title "Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon" @default.
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• W2141290131 doi "https://doi.org/10.1093/nar/gkm1043" @default.
• W2141290131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2532709" @default.
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• W2141290131 hasPublicationYear "2007" @default.
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