FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141316666> ?p ?o ?g. }

• W2141316666 endingPage "5258" @default.
• W2141316666 startingPage "5249" @default.
• W2141316666 abstract "Trafficking and cell adhesion are key properties of cells of the immune system. However, the molecular pathways that control these cellular behaviors are still poorly understood. Cybr is a scaffold protein highly expressed in the hematopoietic/immune system whose physiological role is still unknown. In vitro studies have shown it regulates LFA-1, a crucial molecule in lymphocyte attachment and migration. Cybr also binds cytohesin-1, a guanine nucleotide exchange factor for the ARF GTPases, which affects actin cytoskeleton remodeling during cell migration. Here we show that expression of Cybr in vivo is differentially modulated by type 1 cytokines during lymphocyte maturation. In mice, Cybr deficiency negatively affects leukocytes circulating in blood and lymphocytes present in the lymph nodes. Moreover, in a Th1-polarized mouse model, lymphocyte trafficking is impaired by loss of Cybr, and Cybr-deficient mice with aseptic peritonitis have fewer cells than controls present in the peritoneal cavity, as well as fewer leukocytes leaving the bloodstream. Mutant mice injected with Moloney murine sarcoma/leukemia virus develop significantly larger tumors than wild-type mice and have reduced lymph node enlargement, suggesting reduced cytotoxic T-lymphocyte migration. Taken together, these data support a role for Cybr in leukocyte trafficking, especially in response to proinflammatory cytokines in stress conditions." @default.
• W2141316666 created "2016-06-24" @default.
• W2141316666 creator A5017948966 @default.
• W2141316666 creator A5018500587 @default.
• W2141316666 creator A5023433695 @default.
• W2141316666 creator A5024499528 @default.
• W2141316666 creator A5032758335 @default.
• W2141316666 creator A5045013322 @default.
• W2141316666 creator A5046342653 @default.
• W2141316666 creator A5058093044 @default.
• W2141316666 creator A5058798438 @default.
• W2141316666 creator A5067466991 @default.
• W2141316666 creator A5078604257 @default.
• W2141316666 creator A5090914300 @default.
• W2141316666 date "2006-07-01" @default.
• W2141316666 modified "2023-10-17" @default.
• W2141316666 title "The Scaffold Protein Cybr Is Required for Cytokine-Modulated Trafficking of Leukocytes In Vivo" @default.
• W2141316666 cites W1544874562 @default.
• W2141316666 cites W1556520758 @default.
• W2141316666 cites W1619405781 @default.
• W2141316666 cites W1965316514 @default.
• W2141316666 cites W1969417219 @default.
• W2141316666 cites W1976551786 @default.
• W2141316666 cites W1976886867 @default.
• W2141316666 cites W1982359099 @default.
• W2141316666 cites W1992230824 @default.
• W2141316666 cites W2002293674 @default.
• W2141316666 cites W2002337442 @default.
• W2141316666 cites W201528159 @default.
• W2141316666 cites W2018172915 @default.
• W2141316666 cites W2022666455 @default.
• W2141316666 cites W2024759929 @default.
• W2141316666 cites W2024812783 @default.
• W2141316666 cites W2030487256 @default.
• W2141316666 cites W2036763905 @default.
• W2141316666 cites W2040857731 @default.
• W2141316666 cites W2075631488 @default.
• W2141316666 cites W2089952691 @default.
• W2141316666 cites W2100856949 @default.
• W2141316666 cites W2110925305 @default.
• W2141316666 cites W2116692641 @default.
• W2141316666 cites W2136550950 @default.
• W2141316666 cites W2141924291 @default.
• W2141316666 cites W2149418167 @default.
• W2141316666 cites W2163484280 @default.
• W2141316666 cites W2169068388 @default.
• W2141316666 cites W2410553442 @default.
• W2141316666 cites W2410813441 @default.
• W2141316666 cites W4244632188 @default.
• W2141316666 doi "https://doi.org/10.1128/mcb.02473-05" @default.
• W2141316666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1592701" @default.
• W2141316666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16809763" @default.
• W2141316666 hasPublicationYear "2006" @default.
• W2141316666 type Work @default.
• W2141316666 sameAs 2141316666 @default.
• W2141316666 citedByCount "21" @default.
• W2141316666 countsByYear W21413166662012 @default.
• W2141316666 countsByYear W21413166662013 @default.
• W2141316666 countsByYear W21413166662014 @default.
• W2141316666 countsByYear W21413166662018 @default.
• W2141316666 countsByYear W21413166662021 @default.
• W2141316666 countsByYear W21413166662022 @default.
• W2141316666 countsByYear W21413166662023 @default.
• W2141316666 crossrefType "journal-article" @default.
• W2141316666 hasAuthorship W2141316666A5017948966 @default.
• W2141316666 hasAuthorship W2141316666A5018500587 @default.
• W2141316666 hasAuthorship W2141316666A5023433695 @default.
• W2141316666 hasAuthorship W2141316666A5024499528 @default.
• W2141316666 hasAuthorship W2141316666A5032758335 @default.
• W2141316666 hasAuthorship W2141316666A5045013322 @default.
• W2141316666 hasAuthorship W2141316666A5046342653 @default.
• W2141316666 hasAuthorship W2141316666A5058093044 @default.
• W2141316666 hasAuthorship W2141316666A5058798438 @default.
• W2141316666 hasAuthorship W2141316666A5067466991 @default.
• W2141316666 hasAuthorship W2141316666A5078604257 @default.
• W2141316666 hasAuthorship W2141316666A5090914300 @default.
• W2141316666 hasBestOaLocation W21413166662 @default.
• W2141316666 hasConcept C126619667 @default.
• W2141316666 hasConcept C154317977 @default.
• W2141316666 hasConcept C164027704 @default.
• W2141316666 hasConcept C17991360 @default.
• W2141316666 hasConcept C202751555 @default.
• W2141316666 hasConcept C203014093 @default.
• W2141316666 hasConcept C2776914184 @default.
• W2141316666 hasConcept C2777761686 @default.
• W2141316666 hasConcept C2778690821 @default.
• W2141316666 hasConcept C55493867 @default.
• W2141316666 hasConcept C62478195 @default.
• W2141316666 hasConcept C86803240 @default.
• W2141316666 hasConcept C8891405 @default.
• W2141316666 hasConcept C95444343 @default.
• W2141316666 hasConceptScore W2141316666C126619667 @default.
• W2141316666 hasConceptScore W2141316666C154317977 @default.
• W2141316666 hasConceptScore W2141316666C164027704 @default.
• W2141316666 hasConceptScore W2141316666C17991360 @default.
• W2141316666 hasConceptScore W2141316666C202751555 @default.
• W2141316666 hasConceptScore W2141316666C203014093 @default.
• W2141316666 hasConceptScore W2141316666C2776914184 @default.

• next