Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141330782> ?p ?o ?g. }
- W2141330782 endingPage "742" @default.
- W2141330782 startingPage "731" @default.
- W2141330782 abstract "Abstract Promiscuous enzymes possess activities in addition to their native ones. Promiscuous activities could be remnants from an evolutionary ancestor that has been adapted to fulfil a new function following gene duplication. Alternatively, the observation of promiscuity could indicate that an enzyme has the potential to evolve into a new catalyst. Thus, the observation of promiscuity defines functional relationships in enzyme superfamilies. Crosswise promiscuity can provide an additional layer of connectivity between members of a - usually structurally defined - superfamily to establish a system for tracking the emergence and interconversion of enzymatic function. The systematic analysis of measured promiscuous rates may serve as a basis for drawing up phylogenetic relationships based on the potential for catalysis and may be useful for active use in directed evolution, suggesting evolutionary short cuts. We review recent observations of catalytic promiscuity in members of the alkaline phosphatase (AP) superfamily that exhibit reciprocal relationships of crosswise promiscuity with rate accelerations ( k cat / K M )/ k 2 between 10 6 and 10 18 . Specifically, we focus on the mechanistic features that appear to form the basis of catalytic promiscuity in this superfamily." @default.
- W2141330782 created "2016-06-24" @default.
- W2141330782 creator A5051612157 @default.
- W2141330782 creator A5067633818 @default.
- W2141330782 date "2009-01-01" @default.
- W2141330782 modified "2023-10-18" @default.
- W2141330782 title "Mapping catalytic promiscuity in the alkaline phosphatase superfamily" @default.
- W2141330782 cites W1003489756 @default.
- W2141330782 cites W1572436211 @default.
- W2141330782 cites W1607686261 @default.
- W2141330782 cites W1954690293 @default.
- W2141330782 cites W1965220194 @default.
- W2141330782 cites W1970710213 @default.
- W2141330782 cites W1972607828 @default.
- W2141330782 cites W1976454923 @default.
- W2141330782 cites W1980363424 @default.
- W2141330782 cites W1981923156 @default.
- W2141330782 cites W1985770761 @default.
- W2141330782 cites W1987068920 @default.
- W2141330782 cites W1987696643 @default.
- W2141330782 cites W1987867414 @default.
- W2141330782 cites W1992930517 @default.
- W2141330782 cites W1994593429 @default.
- W2141330782 cites W1995425581 @default.
- W2141330782 cites W1997293305 @default.
- W2141330782 cites W1998238795 @default.
- W2141330782 cites W2001521415 @default.
- W2141330782 cites W2003515662 @default.
- W2141330782 cites W2003836093 @default.
- W2141330782 cites W2008921808 @default.
- W2141330782 cites W2009235439 @default.
- W2141330782 cites W2012332308 @default.
- W2141330782 cites W2017241270 @default.
- W2141330782 cites W2018012868 @default.
- W2141330782 cites W2021928977 @default.
- W2141330782 cites W2025392950 @default.
- W2141330782 cites W2041421251 @default.
- W2141330782 cites W2046522844 @default.
- W2141330782 cites W2049120768 @default.
- W2141330782 cites W2055725315 @default.
- W2141330782 cites W2058606644 @default.
- W2141330782 cites W2060067160 @default.
- W2141330782 cites W2060576889 @default.
- W2141330782 cites W2060661167 @default.
- W2141330782 cites W2060728728 @default.
- W2141330782 cites W2060997255 @default.
- W2141330782 cites W2077335984 @default.
- W2141330782 cites W2080249432 @default.
- W2141330782 cites W2081286132 @default.
- W2141330782 cites W2082260955 @default.
- W2141330782 cites W2082867535 @default.
- W2141330782 cites W2083882673 @default.
- W2141330782 cites W2085277871 @default.
- W2141330782 cites W2095797531 @default.
- W2141330782 cites W2097589722 @default.
- W2141330782 cites W2103731920 @default.
- W2141330782 cites W2105869636 @default.
- W2141330782 cites W2108067237 @default.
- W2141330782 cites W2109855928 @default.
- W2141330782 cites W2110198171 @default.
- W2141330782 cites W2110970545 @default.
- W2141330782 cites W2114814818 @default.
- W2141330782 cites W2116888257 @default.
- W2141330782 cites W2119273654 @default.
- W2141330782 cites W2131605171 @default.
- W2141330782 cites W2133285431 @default.
- W2141330782 cites W2133566550 @default.
- W2141330782 cites W2134713911 @default.
- W2141330782 cites W2135152200 @default.
- W2141330782 cites W2135692259 @default.
- W2141330782 cites W2135900956 @default.
- W2141330782 cites W2139140152 @default.
- W2141330782 cites W2140221090 @default.
- W2141330782 cites W2142962510 @default.
- W2141330782 cites W2144363281 @default.
- W2141330782 cites W2148362768 @default.
- W2141330782 cites W2149669489 @default.
- W2141330782 cites W2152358306 @default.
- W2141330782 cites W2156389360 @default.
- W2141330782 cites W2160754382 @default.
- W2141330782 cites W2161414810 @default.
- W2141330782 cites W2161964918 @default.
- W2141330782 cites W2173919120 @default.
- W2141330782 cites W2313160449 @default.
- W2141330782 cites W2328392914 @default.
- W2141330782 cites W2331377560 @default.
- W2141330782 cites W2952314914 @default.
- W2141330782 cites W2952631364 @default.
- W2141330782 cites W4211062846 @default.
- W2141330782 cites W4211206272 @default.
- W2141330782 cites W4229487902 @default.
- W2141330782 doi "https://doi.org/10.1351/pac-con-08-10-20" @default.
- W2141330782 hasPublicationYear "2009" @default.
- W2141330782 type Work @default.
- W2141330782 sameAs 2141330782 @default.
- W2141330782 citedByCount "56" @default.
- W2141330782 countsByYear W21413307822012 @default.
- W2141330782 countsByYear W21413307822013 @default.