FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141342371> ?p ?o ?g. }

• W2141342371 endingPage "283" @default.
• W2141342371 startingPage "277" @default.
• W2141342371 abstract "Extrahepatic portal vein obstruction (EHPVO) is clinically associated with decreased liver-dependent coagulation factors and smaller than normal liver volumes. We developed a rodent EHPVO model to describe changes in coagulation factor regulation and liver homeostasis.Fifteen rats underwent controlled narrowing of the portal vein (PV) at the hilum, and 15 underwent sham operations. Three animals from each group were sacrificed at postoperative days (PODs) 1, 2, 4, 7, and 21. Their livers were studied for apoptosis, proliferation, and hepatocyte growth factor (HGF) expression using terminal transferase dUTP nick end labeling (TUNEL) assays, Ki-67, and hepatocyte growth factor antibody. Liver total RNA was harvested for reverse transcriptase-polymerase chain reaction (RT-PCR), using primers for factors V, VII, VIII, X, protein C, and antithrombin. Appropriate statistical analysis was applied.Ligation of the portal vein in the experimental group resulted in a 59+/-17% (mean +/- standard deviation) decrease in distal portal vein diameter. Proportional body weight was equivalent in both groups, but spleen weight was higher in the experimental group at PODs 4, 7, 21, and liver weight was higher at POD 7 (p < 0.05). The percentage of apoptotic cells in the experimental group increased from that of the control group at POD 4 (p < 0.05). The percentages of proliferating cells, HGF expression, and factor VII transcription in the experimental group were lower than those of controls at POD 2 (p < 0.05) but higher at POD 7 (p < 0.05). Ki-67/TUNEL double staining showed no grouping of apoptotic and proliferating cells. Factor V transcription in the experimental group was increased compared with that in controls at POD 2 (p < 0.05). Transcription of factors VIII, X, protein C, and antithrombin was unchanged.Our model demonstrated an early increase in hepatocyte apoptosis, impairment of factor VII transcription, and decrease in proliferative indices. These data support the hypothesis that EHPVO disrupts hepatic homeostasis and leads to dysregulation of coagulation factor synthesis." @default.
• W2141342371 created "2016-06-24" @default.
• W2141342371 creator A5002029087 @default.
• W2141342371 creator A5006375381 @default.
• W2141342371 creator A5015240821 @default.
• W2141342371 creator A5051281026 @default.
• W2141342371 creator A5058207258 @default.
• W2141342371 date "2007-08-01" @default.
• W2141342371 modified "2023-09-27" @default.
• W2141342371 title "Factor VII Transcription Correlates with Hepatocyte Proliferation and Hepatocyte Growth Factor Expression in a Rodent Extrahepatic Portal Vein Obstruction Model" @default.
• W2141342371 cites W1563645938 @default.
• W2141342371 cites W1979940920 @default.
• W2141342371 cites W1984207213 @default.
• W2141342371 cites W1992136899 @default.
• W2141342371 cites W2000179823 @default.
• W2141342371 cites W2032761083 @default.
• W2141342371 cites W2034107361 @default.
• W2141342371 cites W2059113865 @default.
• W2141342371 cites W2106190408 @default.
• W2141342371 cites W2114783885 @default.
• W2141342371 cites W2161950721 @default.
• W2141342371 cites W2209268201 @default.
• W2141342371 cites W2414788117 @default.
• W2141342371 doi "https://doi.org/10.1016/j.jamcollsurg.2007.04.005" @default.
• W2141342371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17660074" @default.
• W2141342371 hasPublicationYear "2007" @default.
• W2141342371 type Work @default.
• W2141342371 sameAs 2141342371 @default.
• W2141342371 citedByCount "4" @default.
• W2141342371 countsByYear W21413423712012 @default.
• W2141342371 countsByYear W21413423712014 @default.
• W2141342371 countsByYear W21413423712020 @default.
• W2141342371 crossrefType "journal-article" @default.
• W2141342371 hasAuthorship W2141342371A5002029087 @default.
• W2141342371 hasAuthorship W2141342371A5006375381 @default.
• W2141342371 hasAuthorship W2141342371A5015240821 @default.
• W2141342371 hasAuthorship W2141342371A5051281026 @default.
• W2141342371 hasAuthorship W2141342371A5058207258 @default.
• W2141342371 hasConcept C126322002 @default.
• W2141342371 hasConcept C134018914 @default.
• W2141342371 hasConcept C142724271 @default.
• W2141342371 hasConcept C16685009 @default.
• W2141342371 hasConcept C170493617 @default.
• W2141342371 hasConcept C190283241 @default.
• W2141342371 hasConcept C196795494 @default.
• W2141342371 hasConcept C202751555 @default.
• W2141342371 hasConcept C204232928 @default.
• W2141342371 hasConcept C2776200302 @default.
• W2141342371 hasConcept C2776996007 @default.
• W2141342371 hasConcept C55493867 @default.
• W2141342371 hasConcept C71924100 @default.
• W2141342371 hasConcept C86803240 @default.
• W2141342371 hasConceptScore W2141342371C126322002 @default.
• W2141342371 hasConceptScore W2141342371C134018914 @default.
• W2141342371 hasConceptScore W2141342371C142724271 @default.
• W2141342371 hasConceptScore W2141342371C16685009 @default.
• W2141342371 hasConceptScore W2141342371C170493617 @default.
• W2141342371 hasConceptScore W2141342371C190283241 @default.
• W2141342371 hasConceptScore W2141342371C196795494 @default.
• W2141342371 hasConceptScore W2141342371C202751555 @default.
• W2141342371 hasConceptScore W2141342371C204232928 @default.
• W2141342371 hasConceptScore W2141342371C2776200302 @default.
• W2141342371 hasConceptScore W2141342371C2776996007 @default.
• W2141342371 hasConceptScore W2141342371C55493867 @default.
• W2141342371 hasConceptScore W2141342371C71924100 @default.
• W2141342371 hasConceptScore W2141342371C86803240 @default.
• W2141342371 hasIssue "2" @default.
• W2141342371 hasLocation W21413423711 @default.
• W2141342371 hasLocation W21413423712 @default.
• W2141342371 hasOpenAccess W2141342371 @default.
• W2141342371 hasPrimaryLocation W21413423711 @default.
• W2141342371 hasRelatedWork W1553598265 @default.
• W2141342371 hasRelatedWork W2044988659 @default.
• W2141342371 hasRelatedWork W2077169231 @default.
• W2141342371 hasRelatedWork W2094423915 @default.
• W2141342371 hasRelatedWork W2350569728 @default.
• W2141342371 hasRelatedWork W2360970443 @default.
• W2141342371 hasRelatedWork W2368731425 @default.
• W2141342371 hasRelatedWork W2376666030 @default.
• W2141342371 hasRelatedWork W2380423849 @default.
• W2141342371 hasRelatedWork W2389467880 @default.
• W2141342371 hasVolume "205" @default.
• W2141342371 isParatext "false" @default.
• W2141342371 isRetracted "false" @default.
• W2141342371 magId "2141342371" @default.
• W2141342371 workType "article" @default.