Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141342518> ?p ?o ?g. }
- W2141342518 endingPage "24504" @default.
- W2141342518 startingPage "24498" @default.
- W2141342518 abstract "Causal implication of S100A4 in inducing metastases was convincingly shown previously. However, the mechanisms that associate S100A4 with tumor progression are not well understood. S100A4 protein, as a typical member of the S100 family, exhibits dual, intracellular and extracellular, functions. This work is focused on the extracellular function of S100A4, in particular its involvement in tumor-stroma interplay in VMR (mouse adenocarcinoma cell line) tumor cells, which exhibit stroma-dependent metastatic phenotype. We demonstrated the reciprocal influence of tumor and stroma cells where tumor cells stimulate S100A4 secretion from fibroblasts in culture. In turn, extracellular S100A4 modifies the cytoskeleton and focal adhesions and triggers several other events in tumor cells. We found stabilization of the tumor suppressor protein p53 and modulation of its function. In particular, extracellular S100A4 down-regulates the pro-apoptotic bax and the angiogenesis inhibitor thrombospondin-1 genes. For the first time, we demonstrate here that the S100A4 protein added to the extracellular space strongly stimulates proteolytic activity of VMR cells. This activity most probably is associated with matrix metalloproteinases and, in particular, with matrix metalloproteinase-13. Finally, the application of the recombinant S100A4 protein confers stroma-independent metastatic phenotype on VMR tumor cells. In conclusion, our results indicate that metastasis-inducing S100A4 protein plays a pivotal role in the tumor-stroma environment. S100A4 released either by tumor or stroma cells triggers pro-metastatic cascades in tumor cells. Causal implication of S100A4 in inducing metastases was convincingly shown previously. However, the mechanisms that associate S100A4 with tumor progression are not well understood. S100A4 protein, as a typical member of the S100 family, exhibits dual, intracellular and extracellular, functions. This work is focused on the extracellular function of S100A4, in particular its involvement in tumor-stroma interplay in VMR (mouse adenocarcinoma cell line) tumor cells, which exhibit stroma-dependent metastatic phenotype. We demonstrated the reciprocal influence of tumor and stroma cells where tumor cells stimulate S100A4 secretion from fibroblasts in culture. In turn, extracellular S100A4 modifies the cytoskeleton and focal adhesions and triggers several other events in tumor cells. We found stabilization of the tumor suppressor protein p53 and modulation of its function. In particular, extracellular S100A4 down-regulates the pro-apoptotic bax and the angiogenesis inhibitor thrombospondin-1 genes. For the first time, we demonstrate here that the S100A4 protein added to the extracellular space strongly stimulates proteolytic activity of VMR cells. This activity most probably is associated with matrix metalloproteinases and, in particular, with matrix metalloproteinase-13. Finally, the application of the recombinant S100A4 protein confers stroma-independent metastatic phenotype on VMR tumor cells. In conclusion, our results indicate that metastasis-inducing S100A4 protein plays a pivotal role in the tumor-stroma environment. S100A4 released either by tumor or stroma cells triggers pro-metastatic cascades in tumor cells." @default.
- W2141342518 created "2016-06-24" @default.
- W2141342518 creator A5003023498 @default.
- W2141342518 creator A5008123381 @default.
- W2141342518 creator A5012516349 @default.
- W2141342518 creator A5034127036 @default.
- W2141342518 creator A5068188519 @default.
- W2141342518 creator A5069399294 @default.
- W2141342518 creator A5071960589 @default.
- W2141342518 creator A5078571095 @default.
- W2141342518 creator A5080899662 @default.
- W2141342518 creator A5085138721 @default.
- W2141342518 date "2004-06-01" @default.
- W2141342518 modified "2023-10-18" @default.
- W2141342518 title "Functional Significance of Metastasis-inducing S100A4(Mts1) in Tumor-Stroma Interplay" @default.
- W2141342518 cites W1505763719 @default.
- W2141342518 cites W1520425169 @default.
- W2141342518 cites W1536565076 @default.
- W2141342518 cites W1656339735 @default.
- W2141342518 cites W1668309971 @default.
- W2141342518 cites W1963681491 @default.
- W2141342518 cites W1964745840 @default.
- W2141342518 cites W1976574583 @default.
- W2141342518 cites W1978082261 @default.
- W2141342518 cites W1985301994 @default.
- W2141342518 cites W1990427439 @default.
- W2141342518 cites W1998826717 @default.
- W2141342518 cites W1999258680 @default.
- W2141342518 cites W2001857954 @default.
- W2141342518 cites W2003012091 @default.
- W2141342518 cites W2014927326 @default.
- W2141342518 cites W2018211174 @default.
- W2141342518 cites W2023290310 @default.
- W2141342518 cites W2035666161 @default.
- W2141342518 cites W2053374287 @default.
- W2141342518 cites W2053985126 @default.
- W2141342518 cites W2065140692 @default.
- W2141342518 cites W2072338339 @default.
- W2141342518 cites W2074675359 @default.
- W2141342518 cites W2074698193 @default.
- W2141342518 cites W2084799204 @default.
- W2141342518 cites W2087022087 @default.
- W2141342518 cites W2112603318 @default.
- W2141342518 cites W2122374538 @default.
- W2141342518 cites W2136055108 @default.
- W2141342518 cites W2147894248 @default.
- W2141342518 cites W2149809213 @default.
- W2141342518 cites W2329080279 @default.
- W2141342518 cites W2334141130 @default.
- W2141342518 cites W4235291457 @default.
- W2141342518 cites W4294216491 @default.
- W2141342518 doi "https://doi.org/10.1074/jbc.m400441200" @default.
- W2141342518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15047714" @default.
- W2141342518 hasPublicationYear "2004" @default.
- W2141342518 type Work @default.
- W2141342518 sameAs 2141342518 @default.
- W2141342518 citedByCount "139" @default.
- W2141342518 countsByYear W21413425182012 @default.
- W2141342518 countsByYear W21413425182013 @default.
- W2141342518 countsByYear W21413425182014 @default.
- W2141342518 countsByYear W21413425182015 @default.
- W2141342518 countsByYear W21413425182016 @default.
- W2141342518 countsByYear W21413425182017 @default.
- W2141342518 countsByYear W21413425182018 @default.
- W2141342518 countsByYear W21413425182019 @default.
- W2141342518 countsByYear W21413425182020 @default.
- W2141342518 countsByYear W21413425182021 @default.
- W2141342518 countsByYear W21413425182022 @default.
- W2141342518 countsByYear W21413425182023 @default.
- W2141342518 crossrefType "journal-article" @default.
- W2141342518 hasAuthorship W2141342518A5003023498 @default.
- W2141342518 hasAuthorship W2141342518A5008123381 @default.
- W2141342518 hasAuthorship W2141342518A5012516349 @default.
- W2141342518 hasAuthorship W2141342518A5034127036 @default.
- W2141342518 hasAuthorship W2141342518A5068188519 @default.
- W2141342518 hasAuthorship W2141342518A5069399294 @default.
- W2141342518 hasAuthorship W2141342518A5071960589 @default.
- W2141342518 hasAuthorship W2141342518A5078571095 @default.
- W2141342518 hasAuthorship W2141342518A5080899662 @default.
- W2141342518 hasAuthorship W2141342518A5085138721 @default.
- W2141342518 hasBestOaLocation W21413425181 @default.
- W2141342518 hasConcept C121608353 @default.
- W2141342518 hasConcept C16930146 @default.
- W2141342518 hasConcept C189165786 @default.
- W2141342518 hasConcept C203014093 @default.
- W2141342518 hasConcept C204232928 @default.
- W2141342518 hasConcept C2776107976 @default.
- W2141342518 hasConcept C2779013556 @default.
- W2141342518 hasConcept C2779256057 @default.
- W2141342518 hasConcept C2780394083 @default.
- W2141342518 hasConcept C28406088 @default.
- W2141342518 hasConcept C3020616263 @default.
- W2141342518 hasConcept C502942594 @default.
- W2141342518 hasConcept C52124034 @default.
- W2141342518 hasConcept C54355233 @default.
- W2141342518 hasConcept C86803240 @default.
- W2141342518 hasConcept C95444343 @default.
- W2141342518 hasConceptScore W2141342518C121608353 @default.