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- W2141377672 abstract "We present a series of hydrogel nanoparticles (nanogels) incorporating either acyclic or cyclic gadolinium chelates as crosslinkers. These crosslinkers are used to formulate polyacrylamide-based nanogels (diameter 50 to 85 nm) yielding contrast agents with enhanced relaxivities (up to 6-fold greater than Dotarem®), because the nanogel structure slows the chelator's tumbling frequency and allows fast water exchange. Importantly, these nanogels also stabilize Gd3+ within the chelator thermodynamically and kinetically against metal displacement through transmetallation, which should reduce toxicity associated with release of free Gd3+. This chelation stability suggests that the chelate crosslinker strategy may prove useful for other applications of metal-chelating nanoparticles in medicine, including other imaging modalities and radiotherapy." @default.
- W2141377672 created "2016-06-24" @default.
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- W2141377672 date "2013-01-01" @default.
- W2141377672 modified "2023-10-14" @default.
- W2141377672 title "Metal chelating crosslinkers form nanogels with high chelation stability" @default.
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- W2141377672 doi "https://doi.org/10.1039/c3tb21104e" @default.
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