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• W2141408773 abstract "Typical aging is associated with diminished episodic memory performance. To improve our understanding of the fundamental mechanisms underlying this age-related memory deficit, we previously developed an integrated, cross-species approach to link converging evidence from human and animal research. This novel approach focuses on the ability to remember sequences of events, an important feature of episodic memory. Unlike existing paradigms, this task is nonspatial, nonverbal, and can be used to isolate different cognitive processes that may be differentially affected in aging. Here, we used this task to make a comprehensive comparison of sequence memory performance between younger (18–22 yr) and older adults (62–86 yr). Specifically, participants viewed repeated sequences of six colored, fractal images and indicated whether each item was presented “in sequence” or “out of sequence.” Several out of sequence probe trials were used to provide a detailed assessment of sequence memory, including: (i) repeating an item from earlier in the sequence (“Repeats”; e.g., AB A DEF), (ii) skipping ahead in the sequence (“Skips”; e.g., AB D DEF), and (iii) inserting an item from a different sequence into the same ordinal position (“Ordinal Transfers”; e.g., AB 3 DEF). We found that older adults performed as well as younger controls when tested on well-known and predictable sequences, but were severely impaired when tested using novel sequences. Importantly, overall sequence memory performance in older adults steadily declined with age, a decline not detected with other measures (RAVLT or BPS-O). We further characterized this deficit by showing that performance of older adults was severely impaired on specific probe trials that required detailed knowledge of the sequence (Skips and Ordinal Transfers), and was associated with a shift in their underlying mnemonic representation of the sequences. Collectively, these findings provide unambiguous evidence that the capacity to remember sequences of events is fundamentally affected by typical aging." @default.
• W2141408773 created "2016-06-24" @default.
• W2141408773 creator A5002353138 @default.
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• W2141408773 date "2015-02-17" @default.
• W2141408773 modified "2023-09-24" @default.
• W2141408773 title "Memory for sequences of events impaired in typical aging" @default.
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• W2141408773 cites W1656983431 @default.
• W2141408773 cites W1847168837 @default.
• W2141408773 cites W195292635 @default.
• W2141408773 cites W1967220580 @default.
• W2141408773 cites W1967305188 @default.
• W2141408773 cites W1969035214 @default.
• W2141408773 cites W1969736263 @default.
• W2141408773 cites W1970006557 @default.
• W2141408773 cites W1971327899 @default.
• W2141408773 cites W1971761527 @default.
• W2141408773 cites W1982186402 @default.
• W2141408773 cites W1982667640 @default.
• W2141408773 cites W1983949152 @default.
• W2141408773 cites W1988617650 @default.
• W2141408773 cites W1989019473 @default.
• W2141408773 cites W1993475351 @default.
• W2141408773 cites W1993620214 @default.
• W2141408773 cites W1995549508 @default.
• W2141408773 cites W1996347415 @default.
• W2141408773 cites W1999717910 @default.
• W2141408773 cites W2000658575 @default.
• W2141408773 cites W2001788447 @default.
• W2141408773 cites W2005016731 @default.
• W2141408773 cites W2005101532 @default.
• W2141408773 cites W2005192366 @default.
• W2141408773 cites W2007128258 @default.
• W2141408773 cites W2008854521 @default.
• W2141408773 cites W2009301825 @default.
• W2141408773 cites W2011974449 @default.
• W2141408773 cites W2016986221 @default.
• W2141408773 cites W2018129512 @default.
• W2141408773 cites W2019970707 @default.
• W2141408773 cites W2022686017 @default.
• W2141408773 cites W2033605145 @default.
• W2141408773 cites W2034470020 @default.
• W2141408773 cites W2035017430 @default.
• W2141408773 cites W2035413814 @default.
• W2141408773 cites W2037850102 @default.
• W2141408773 cites W2045175155 @default.
• W2141408773 cites W2050084287 @default.
• W2141408773 cites W2050636233 @default.
• W2141408773 cites W2051692581 @default.
• W2141408773 cites W2053292822 @default.
• W2141408773 cites W2054712601 @default.
• W2141408773 cites W2055746469 @default.
• W2141408773 cites W2055964704 @default.
• W2141408773 cites W2058161128 @default.
• W2141408773 cites W2067065650 @default.
• W2141408773 cites W2067622536 @default.
• W2141408773 cites W2075684710 @default.
• W2141408773 cites W2076536312 @default.
• W2141408773 cites W2079116631 @default.
• W2141408773 cites W2084391069 @default.
• W2141408773 cites W2091999943 @default.
• W2141408773 cites W2093362207 @default.
• W2141408773 cites W2095882961 @default.
• W2141408773 cites W2103069600 @default.
• W2141408773 cites W2103861118 @default.
• W2141408773 cites W2105089471 @default.
• W2141408773 cites W2107406220 @default.
• W2141408773 cites W2116464190 @default.
• W2141408773 cites W2120864281 @default.
• W2141408773 cites W2123081263 @default.
• W2141408773 cites W2124043650 @default.
• W2141408773 cites W2128560214 @default.
• W2141408773 cites W2130099840 @default.
• W2141408773 cites W2132361590 @default.
• W2141408773 cites W2138117749 @default.
• W2141408773 cites W2140641297 @default.
• W2141408773 cites W2144225695 @default.
• W2141408773 cites W2147970286 @default.
• W2141408773 cites W2147973220 @default.
• W2141408773 cites W2148080316 @default.
• W2141408773 cites W2150030818 @default.
• W2141408773 cites W2150862320 @default.
• W2141408773 cites W2167311298 @default.
• W2141408773 cites W2168516263 @default.
• W2141408773 cites W4205599946 @default.
• W2141408773 cites W4230399697 @default.
• W2141408773 cites W4231239618 @default.
• W2141408773 cites W4234477066 @default.
• W2141408773 cites W4240516459 @default.
• W2141408773 cites W640247072 @default.
• W2141408773 cites W1598728220 @default.
• W2141408773 doi "https://doi.org/10.1101/lm.036301.114" @default.
• W2141408773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4340129" @default.
• W2141408773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25691514" @default.

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