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• W2141440036 endingPage "244" @default.
• W2141440036 startingPage "237" @default.
• W2141440036 abstract "Nonenzymatic glycation of proteins, leading to chemical modification and cross-linking are of importance in the pathology of diabetic complications.We studied the effect of α -lipoic acid (LA) on the content and characteristics of the protein collagen from skin of high-fructose fed rats. The rats were divided into 4 groups of 6 each. Two groups of rats were fed with a high fructose diet (60 g/100 g diet) and administered either LA (35 mg/kg b.w., i.p) (FRU+LA) or 0.2 ml vehicle (saline) (FRU) for 45 days. The other 2 groups were fed with control diet containing starch (60 g/100 g diet) and administered either saline (CON) or lipoic acid (CON+LA). The rats were maintained for 45 days and then sacrificed. Plasma glucose, insulin, fructosamine, protein glycation, and blood glycated hemoglobin (Hb<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E1><mml:msub><mml:mtext>A</mml:mtext><mml:mn>1</mml:mn></mml:msub></mml:math>C) were measured. Collagen was isolated from skin and the physicochemical properties of collagen were studied. Fructose administration caused accumulation of collagen in skin. Extensive cross-linking was evidenced by enhanced glycation and AGE-linked fluorescence. Increased peroxidation and changes in physicochemical properties such as shrinkage temperature, aldehyde content, solubililty pattern, susceptibility to denaturing agents were observed in fructose-fed rats. SDS gel pattern of collagen from these rats showed elevated β component of type I collagen. These changes were alleviated by the simultaneous administration of LA. Administration of LA to fructose-fed rats had a positive influence on both quantitative and qualitative properties of collagen. The results suggest a mechanism for the ability of LA to delay diabetic complications." @default.
• W2141440036 created "2016-06-24" @default.
• W2141440036 creator A5033190756 @default.
• W2141440036 creator A5074570923 @default.
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• W2141440036 date "2004-01-01" @default.
• W2141440036 modified "2023-09-26" @default.
• W2141440036 title "Fructose Diet-Induced Skin Collagen Abnormalities Are Prevented by Lipoic Acid" @default.
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• W2141440036 doi "https://doi.org/10.1080/154386090506148" @default.
• W2141440036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2478634" @default.
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• W2141440036 hasPublicationYear "2004" @default.
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