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- W2141445871 abstract "Background: A high-sensitivity cardiac troponin T (hs-cTnT) concentration above the 99th percentile (i.e. 14 ng/L) is common during Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and associated with increased mortality. Objective: To identify factors predictive of hs-cTnT levels during AECOPD. Methods: We included 99 patients with AECOPD on admission. As several patients had repeat admissions, there are 219 observations. We recorded clinical data, medication, spirometry, chest radiographs, ECG data and biochemical data including serum creatinine, hs-cTnT, and NT-proBNP. The data were analysed using a general linear mixed model with the natural logarithm of hs-cTnT as the dependent variable. Results: Mean age at inclusion was 71.5 years, mean FEV 1 was 37% of predicted, and median hs-cTnT was 39.7 ng/L. The variables associated with hs-cTnT (p 2 , creatinine, neutrophil count, NT-proBNP, and infiltrate and cephalisation on chest radiograph. In a multivariable model, patient age, history of hypertension, cephalisation, tachycardia, creatinine, neutrophil count >11.5×10 9 /L, and NT-proBNP remained significantly associated (p Conclusion: Multiple variables, including those reflecting heart failure, renal dysfunction, and inflammation are predictive of hs-cTnT during AECOPD, suggesting that the mechanisms underlying hs-cTnT elevation are multifactorial." @default.
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- W2141445871 date "2011-09-01" @default.
- W2141445871 modified "2023-09-26" @default.
- W2141445871 title "Predictors of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease" @default.
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