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• W2141454385 abstract "• Although voltage clamp methods have been applied experimentally to cardiac tissue for over a decade, this field of study has failed to achieve general acceptance because of limitations of the experimental approach and difficulty in interpreting the results. Yet this technique is valuable within its limitations, and to dismiss it would be to lose a valuable tool. In perspective, most techniques in biological investigations have equivalent limitations. In this brief review we attempt to summarize the rationale behind the approach, the nature and tractability of limitations in the approach, and the results that we believe can be drawn safely from experimental studies to date. It is our hope that this review will serve to place the field in better perspective for the nonclamper than have the more detailed reviews in the past and that it will simultaneously indicate the future growth and trends in this field as we see them. WHY VOLTAGE CLAMP? Excitation and contraction are two fundamental properties of heart muscle that are of general interest. Normally, a locally generated action potential propagates throughout the heart, generating the familiar electrocardiogram. This electrical event at the cell membrane triggers the contraction by some unknown process, generally called excitation-contraction coupling. The great importance of these properties of heart muscle in the understanding of normal cardiac function has made them a major area for electrophysiological study. Also, since many pathological conditions or treatment modalities are characterized by alterations in excitation or contraction, these areas receive much clinical interest. The primary tool in the study of excitation or" @default.
• W2141454385 created "2016-06-24" @default.
• W2141454385 creator A5002016443 @default.
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• W2141454385 date "1975-10-01" @default.
• W2141454385 modified "2023-09-25" @default.
• W2141454385 title "The voltage clamp and cardiac electrophysiology." @default.
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• W2141454385 doi "https://doi.org/10.1161/01.res.37.4.403" @default.
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