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• W2141455079 abstract "ABSTRACT A mitochondrial HSP70 gene ( Cp-mtHSP70 ) is described for the apicomplexan Cryptosporidium parvum , an agent of diarrhea in humans and animals. Mitochondrial HSP70 is known to have been acquired from the proto-mitochondrial endosymbiont. The amino acid sequence of Cp-mtHSP70 shares common domains with mitochondrial and proteobacterial homologues, including 34 amino acids of an NH 2 -terminal mitochondrion-like targeting presequence. Phylogenetic reconstruction places Cp-mtHSP70 within the mitochondrial clade of HSP70 homologues. Using reverse transcription-PCR, Cp-mtHSP70 mRNA was observed in C. parvum intracellular stages cultured in HCT-8 cells. Polyclonal antibodies to Cp-mtHSP70 recognize a ∼70-kDa protein in Western blot analysis of sporozoite extracts. Both fluorescein- and immunogold-labeled anti-Cp-mtHSP70 localize to a single mitochondrial compartment in close apposition to the nucleus. Furthermore, the NH 2 -terminal presequence of Cp-mtHSP70 can correctly target green fluorescent protein to the single mitochondrion of the apicomplexan Toxoplasma gondii and the mitochondrial network of the yeast Saccharomyces cerevisiae . When this presequence was truncated, the predicted amphiphilic α-helix was shown to be essential for import into the yeast mitochondrion. These data further support the presence of a secondarily reduced relict mitochondrion in C. parvum ." @default.
• W2141455079 created "2016-06-24" @default.
• W2141455079 creator A5013532722 @default.
• W2141455079 creator A5059788187 @default.
• W2141455079 date "2004-04-01" @default.
• W2141455079 modified "2023-10-13" @default.
• W2141455079 title "<i>Cryptosporidium parvum</i> Mitochondrial-Type HSP70 Targets Homologous and Heterologous Mitochondria" @default.
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• W2141455079 doi "https://doi.org/10.1128/ec.3.2.483-494.2004" @default.
• W2141455079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/387664" @default.
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