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• W2141479374 endingPage "e0122401" @default.
• W2141479374 startingPage "e0122401" @default.
• W2141479374 abstract "The equilibrium Nernst potential plays a critical role in neural cell dynamics. A common approximation used in studying electrical dynamics of excitable cells is that the ionic concentrations inside and outside the cell membranes act as charge reservoirs and remain effectively constant during excitation events. Research into brain electrical activity suggests that relaxing this assumption may provide a better understanding of normal and pathophysiological functioning of the brain. In this paper we explore time-dependent ionic concentrations by allowing the ion-specific Nernst potentials to vary with developing transmembrane potential. As a specific implementation, we incorporate the potential-dependent Nernst shift into a one-dimensional Morris-Lecar reaction-diffusion model. Our main findings result from a region in parameter space where self-sustaining oscillations occur without external forcing. Studying the system close to the bifurcation boundary, we explore the vulnerability of the system with respect to external stimulations which disrupt these oscillations and send the system to a stable equilibrium. We also present results for an extended, one-dimensional cable of excitable tissue tuned to this parameter regime and stimulated, giving rise to complex spatiotemporal pattern formation. Potential applications to the emergence of neuronal bursting in similar two-variable systems and to pathophysiological seizure-like activity are discussed." @default.
• W2141479374 created "2016-06-24" @default.
• W2141479374 creator A5028101538 @default.
• W2141479374 creator A5072676635 @default.
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• W2141479374 date "2015-03-30" @default.
• W2141479374 modified "2023-10-15" @default.
• W2141479374 title "Bursting Regimes in a Reaction-Diffusion System with Action Potential-Dependent Equilibrium" @default.
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• W2141479374 doi "https://doi.org/10.1371/journal.pone.0122401" @default.
• W2141479374 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4379183" @default.
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• W2141479374 hasPublicationYear "2015" @default.
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