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• W2141489062 abstract "Evidence is discussed that apical CFTR Cl− channels of mitochondria-rich (MR) cells of Bufo bufo skin conduct β-adrenergic receptor-activated Cl− currents. Ussing chamber studies revealed the following selectivity sequence of the receptor activated conductance, Cl−>Br−>NO3−>I−. With ion selective microelectrode-techniques, it was shown that receptor-coupled Cl− channels are not located in principal cells. A small conductance (7–10 pS) CFTR-like Cl− channel is located in the apical plasma membrane of MR cells. Short life times of sealed patches prevented detailed study of its selectivity to other halide ions and its molecular regulation. With monoclonal hCFTR-antibodies, selective expression in MR cells of the targeted antigens could be demonstrated. A transcript of CFTR was amplified in the skin, and a bbCFTR cDNA clone was generated from toad skin mRNA that exhibits 89% amino acid identity with the human homologue. The frequency of obtaining channels in patch clamp studies was too low for accounting quantitatively for the macroscopic conductance. Since MR cells were isolated by trypsin, and a putative extracellular loop of the deduced bbCFTR protein contains a target peptide bond for trypsin, enzyme treatment may have destroyed apical CFTR molecules." @default.
• W2141489062 created "2016-06-24" @default.
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• W2141489062 date "2001-10-01" @default.
• W2141489062 modified "2023-09-27" @default.
• W2141489062 title "Expression of cystic fibrosis transmembrane conductance regulator in the skin of the toad, Bufo bufo and possible role for Cl− transport across the heterocellular epithelium" @default.
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• W2141489062 doi "https://doi.org/10.1016/s1095-6433(01)00432-9" @default.
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• W2141489062 hasPublicationYear "2001" @default.
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