Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141505412> ?p ?o ?g. }
- W2141505412 endingPage "4937" @default.
- W2141505412 startingPage "4933" @default.
- W2141505412 abstract "High-dose therapy with autologous stem-cell transplantation (HDT-ASCT) is now almost standard therapy for many patients with multiple myeloma, partly because of higher complete response (CR) rates. Some studies suggest that tandem transplantation gives superior results. The aim of this study was to determine whether the depth of the response to HDT-ASCT leads to an improvement in time to progression (TTP) and overall survival (OS). We hypothesized that patients with CR before HDT-ASCT (BCR) will have their disease burden reduced further and experience a longer TTP and perhaps OS.All patients who achieved BCR or CR after HDT-ASCT (ACR) were identified. The characteristics and long-term outcome of these patients were evaluated.We identified 14 patients with BCR and 103 patients with ACR who were treated in similar fashion. The patients have been followed for more than 6 years, and the median for OS has not been reached (60-month survival, 55% for BCR and 63% for ACR; P = .83). The median TTP was 43 months for BCR and 34 months for ACR (P = .39).The depth of the response in myeloma does not necessarily lead to an improvement in TTP and OS. Tumor dynamics considerations show that the yield from sequential cycles of chemotherapy decreases. Patients who achieve CR with the first transplant can be safely observed without jeopardizing OS." @default.
- W2141505412 created "2016-06-24" @default.
- W2141505412 creator A5000308170 @default.
- W2141505412 creator A5001453763 @default.
- W2141505412 creator A5002248011 @default.
- W2141505412 creator A5007747233 @default.
- W2141505412 creator A5026574827 @default.
- W2141505412 creator A5061713890 @default.
- W2141505412 creator A5073403497 @default.
- W2141505412 creator A5076611748 @default.
- W2141505412 creator A5090561132 @default.
- W2141505412 date "2007-11-01" @default.
- W2141505412 modified "2023-09-27" @default.
- W2141505412 title "Relationship Between Depth of Response and Outcome in Multiple Myeloma" @default.
- W2141505412 cites W1703016739 @default.
- W2141505412 cites W182568540 @default.
- W2141505412 cites W1978377409 @default.
- W2141505412 cites W1992231323 @default.
- W2141505412 cites W1995246165 @default.
- W2141505412 cites W1997353354 @default.
- W2141505412 cites W2006914937 @default.
- W2141505412 cites W2028752742 @default.
- W2141505412 cites W20342555 @default.
- W2141505412 cites W2060496777 @default.
- W2141505412 cites W2062707603 @default.
- W2141505412 cites W2080761248 @default.
- W2141505412 cites W2082520586 @default.
- W2141505412 cites W2086692682 @default.
- W2141505412 cites W2101644085 @default.
- W2141505412 cites W2102591890 @default.
- W2141505412 cites W2107057207 @default.
- W2141505412 cites W2108235071 @default.
- W2141505412 cites W2120474651 @default.
- W2141505412 cites W2136256331 @default.
- W2141505412 cites W2136738128 @default.
- W2141505412 cites W2148188974 @default.
- W2141505412 cites W2148672632 @default.
- W2141505412 cites W2152333590 @default.
- W2141505412 cites W2158470148 @default.
- W2141505412 cites W2166517289 @default.
- W2141505412 cites W22172272 @default.
- W2141505412 cites W2313830706 @default.
- W2141505412 cites W2318674152 @default.
- W2141505412 cites W2321655863 @default.
- W2141505412 cites W2339293928 @default.
- W2141505412 cites W2609515889 @default.
- W2141505412 cites W3145716452 @default.
- W2141505412 cites W4236730981 @default.
- W2141505412 cites W4237181574 @default.
- W2141505412 cites W4376542883 @default.
- W2141505412 cites W4378951223 @default.
- W2141505412 doi "https://doi.org/10.1200/jco.2007.11.7879" @default.
- W2141505412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17971591" @default.
- W2141505412 hasPublicationYear "2007" @default.
- W2141505412 type Work @default.
- W2141505412 sameAs 2141505412 @default.
- W2141505412 citedByCount "41" @default.
- W2141505412 countsByYear W21415054122012 @default.
- W2141505412 countsByYear W21415054122013 @default.
- W2141505412 countsByYear W21415054122014 @default.
- W2141505412 countsByYear W21415054122015 @default.
- W2141505412 countsByYear W21415054122018 @default.
- W2141505412 countsByYear W21415054122021 @default.
- W2141505412 countsByYear W21415054122023 @default.
- W2141505412 crossrefType "journal-article" @default.
- W2141505412 hasAuthorship W2141505412A5000308170 @default.
- W2141505412 hasAuthorship W2141505412A5001453763 @default.
- W2141505412 hasAuthorship W2141505412A5002248011 @default.
- W2141505412 hasAuthorship W2141505412A5007747233 @default.
- W2141505412 hasAuthorship W2141505412A5026574827 @default.
- W2141505412 hasAuthorship W2141505412A5061713890 @default.
- W2141505412 hasAuthorship W2141505412A5073403497 @default.
- W2141505412 hasAuthorship W2141505412A5076611748 @default.
- W2141505412 hasAuthorship W2141505412A5090561132 @default.
- W2141505412 hasBestOaLocation W21415054121 @default.
- W2141505412 hasConcept C126322002 @default.
- W2141505412 hasConcept C126894567 @default.
- W2141505412 hasConcept C141071460 @default.
- W2141505412 hasConcept C143998085 @default.
- W2141505412 hasConcept C2776364478 @default.
- W2141505412 hasConcept C2776694085 @default.
- W2141505412 hasConcept C2779050716 @default.
- W2141505412 hasConcept C2911091166 @default.
- W2141505412 hasConcept C3019096185 @default.
- W2141505412 hasConcept C71924100 @default.
- W2141505412 hasConceptScore W2141505412C126322002 @default.
- W2141505412 hasConceptScore W2141505412C126894567 @default.
- W2141505412 hasConceptScore W2141505412C141071460 @default.
- W2141505412 hasConceptScore W2141505412C143998085 @default.
- W2141505412 hasConceptScore W2141505412C2776364478 @default.
- W2141505412 hasConceptScore W2141505412C2776694085 @default.
- W2141505412 hasConceptScore W2141505412C2779050716 @default.
- W2141505412 hasConceptScore W2141505412C2911091166 @default.
- W2141505412 hasConceptScore W2141505412C3019096185 @default.
- W2141505412 hasConceptScore W2141505412C71924100 @default.
- W2141505412 hasIssue "31" @default.
- W2141505412 hasLocation W21415054121 @default.
- W2141505412 hasLocation W21415054122 @default.