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- W2141531208 abstract "Two synthetic analogs of neuropephde FF (NPFF, isolated from bovine brain (1)), D.Tyr-Leu-(NMe)Phe-Gln-Pro-Gln-Arg-Phe-NH 2 [(1DME)Y8Fa] and D.Tyr-D.Leu-D.Phe-Gln-Pro-Gln-Arg-Phe-NH 2 [(3D)Y8Fa], resistant to degradation and possessing a high affinity to the NPFF receptors (2), are able to modulate opioid antinociception after i.c.v. injection (3, 4). Previous reports have suggested a modulatory role of NPFF in opioid (5) and α 2 -adrenergic (6) action in the spinal cord and we have recently reported that NPFF injected intrathecally in the rat can act as antinociceptive agent and can modulate spinal opioid functions (7)" @default.
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- W2141531208 date "1994-02-01" @default.
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- W2141531208 title "Analogs of neuropeptide FF modulate spinal nociception in the rat" @default.
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- W2141531208 doi "https://doi.org/10.1016/0167-0115(94)90267-4" @default.
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