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- W2141532007 abstract "Oropharyngeal candidiasis (OPC), as opposed to vulvovaginal candidiasis (VVC), is a common opportunistic infection in human immunodeficiency virus (HIV)-positive persons that correlates with reduced CD4 T cell counts. Although cell-mediated immunity (CMI) by CD4 Th1-type cells is considered to be the predominant host defense against mucosal candidiasis, the immune factors associated with susceptibility to OPC in HIV-positive persons are not well understood. This study investigated Candida-specific systemic CMI in HIV-positive persons with OPC and/or VVC. Reductions in delayed skin test reactivity to Candida antigen were observed in HIV-positive persons with CD4 cell counts <200 cells/microL, irrespective of the presence of mucosal infection. Likewise, despite the correlate of OPC with reduced CD4 cell counts in HIV-positive persons, differences in Candida-specific peripheral blood mononuclear cell proliferation and Th1/Th2 cytokine production between HIV-positive and HIV-negative persons were not consistent in a manner to suggest that deficiencies in Candida-specific systemic CMI account solely for the susceptibility to OPC." @default.
- W2141532007 created "2016-06-24" @default.
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- W2141532007 date "2001-01-15" @default.
- W2141532007 modified "2023-09-28" @default.
- W2141532007 title "<i>Candida</i>‐Specific Systemic Cell‐Mediated Immune Reactivities in Human Immunodeficiency Virus–Positive Persons with Mucosal Candidiasis" @default.
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- W2141532007 doi "https://doi.org/10.1086/317944" @default.
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