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• W2141549675 startingPage "1111" @default.
• W2141549675 abstract "Cell death is an important physiological regulator during development, tissue homeostasis and stress response but it is also a protective tumor suppressive mechanism. Tumor cells almost universally acquire the ability to evade cell death pathways that in normal cells act as a protective mechanism to remove damaged cells. As a result, a population of death-resistant cells with accumulating genetic and epigenetic abnormalities contributes to malignant transformation. Any alteration of the homeostatic balance between survival and death is therefore a critical factor in carcinogenesis. Several forms of cell death exist and cross talk among them is emerging; however, we still miss many molecular details. It becomes essential to revisit the role of each type of cell death to understand interconnections existing between different cell death pathways as well as the network of their mediators to eventually develop new effective strategies to kill cancer cells. More specifically, new therapies based on compounds selectively triggering apoptosis, necrosis or autophagy recently became both appealing and challenging. Despite the rather clear classification of the different cell death modalities according to morphological criteria and the attempt to describe them with distinct signaling pathways, the reality reveals a complex interplay between apoptosis, regulated necrosis and autophagy involving a heterogeneous mix of molecular mediators. Nature, presenting an almost endless plenitude of bioactive scaffolds, can efficiently contribute compounds that allow deciphering the intricate pathways of cell death pathways and thus eventually contribute to selectively target cancer-type specific pathways in an attempt to personalize cancer patient treatment depending on cancer death pathway specificities. The aim of this review is to provide first an overview of molecular cell death specificities and to highlight how compounds of natural origins, with or without hemisynthetic modifications, target unique thanatotic molecular constellations." @default.
• W2141549675 created "2016-06-24" @default.
• W2141549675 creator A5018593253 @default.
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• W2141549675 creator A5067297017 @default.
• W2141549675 creator A5089909449 @default.
• W2141549675 date "2014-11-01" @default.
• W2141549675 modified "2023-09-30" @default.
• W2141549675 title "From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment" @default.
• W2141549675 cites W1492587973 @default.
• W2141549675 cites W1523845694 @default.
• W2141549675 cites W1527376450 @default.
• W2141549675 cites W1892905988 @default.
• W2141549675 cites W1942231156 @default.
• W2141549675 cites W1964165239 @default.
• W2141549675 cites W1964625584 @default.
• W2141549675 cites W1965931924 @default.
• W2141549675 cites W1966257707 @default.
• W2141549675 cites W1968517023 @default.
• W2141549675 cites W1968962983 @default.
• W2141549675 cites W1969540068 @default.
• W2141549675 cites W1970961784 @default.
• W2141549675 cites W1973981954 @default.
• W2141549675 cites W1974987314 @default.
• W2141549675 cites W1976720365 @default.
• W2141549675 cites W1978514556 @default.
• W2141549675 cites W1978619135 @default.
• W2141549675 cites W1978894503 @default.
• W2141549675 cites W1979948467 @default.
• W2141549675 cites W1980254337 @default.
• W2141549675 cites W1980687166 @default.
• W2141549675 cites W1981192603 @default.
• W2141549675 cites W1982254984 @default.
• W2141549675 cites W1984122112 @default.
• W2141549675 cites W1985072203 @default.
• W2141549675 cites W1986978728 @default.
• W2141549675 cites W1987695408 @default.
• W2141549675 cites W1988924112 @default.
• W2141549675 cites W1989183491 @default.
• W2141549675 cites W1992435071 @default.
• W2141549675 cites W1993262772 @default.
• W2141549675 cites W1995332924 @default.
• W2141549675 cites W1995560549 @default.
• W2141549675 cites W1996114270 @default.
• W2141549675 cites W1998365584 @default.
• W2141549675 cites W1998756818 @default.
• W2141549675 cites W1999606433 @default.
• W2141549675 cites W2000319415 @default.
• W2141549675 cites W2000342880 @default.
• W2141549675 cites W2000732112 @default.
• W2141549675 cites W2001399725 @default.
• W2141549675 cites W2001964408 @default.
• W2141549675 cites W2002959397 @default.
• W2141549675 cites W2003216335 @default.
• W2141549675 cites W2003380425 @default.
• W2141549675 cites W2005289326 @default.
• W2141549675 cites W2012053348 @default.
• W2141549675 cites W2013996883 @default.
• W2141549675 cites W2014687633 @default.
• W2141549675 cites W2015749195 @default.
• W2141549675 cites W2017098230 @default.
• W2141549675 cites W2017813632 @default.
• W2141549675 cites W2021126994 @default.
• W2141549675 cites W2025336062 @default.
• W2141549675 cites W2025367550 @default.
• W2141549675 cites W2025539378 @default.
• W2141549675 cites W2026322409 @default.
• W2141549675 cites W2026958018 @default.
• W2141549675 cites W2029712223 @default.
• W2141549675 cites W2034132952 @default.
• W2141549675 cites W2034251995 @default.
• W2141549675 cites W2036057941 @default.
• W2141549675 cites W2038596058 @default.
• W2141549675 cites W2038683465 @default.
• W2141549675 cites W2039308492 @default.
• W2141549675 cites W2040831361 @default.
• W2141549675 cites W2040907359 @default.
• W2141549675 cites W2041943889 @default.
• W2141549675 cites W2042409437 @default.
• W2141549675 cites W2043260309 @default.
• W2141549675 cites W2043310375 @default.
• W2141549675 cites W2044256186 @default.
• W2141549675 cites W2045058305 @default.
• W2141549675 cites W2047521557 @default.
• W2141549675 cites W2048454522 @default.
• W2141549675 cites W2048929501 @default.
• W2141549675 cites W2050551220 @default.
• W2141549675 cites W2051498560 @default.
• W2141549675 cites W2051790985 @default.
• W2141549675 cites W2052004281 @default.
• W2141549675 cites W2052041444 @default.
• W2141549675 cites W2052475208 @default.
• W2141549675 cites W2052853635 @default.
• W2141549675 cites W2054389254 @default.
• W2141549675 cites W2054395224 @default.
• W2141549675 cites W2057108003 @default.
• W2141549675 cites W2058907296 @default.

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