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• W2141551169 abstract "In European rheumatoid arthritis (RA) patients, the strongest genetic effects are conferred by the HLA-DRB1 locus1 and the protein tyrosine phosphatase 22 gene ( PTPN22 ).2 A further three susceptibility loci ( OLIG3 / TNFAIP3 , TRAF1 / C5 and STAT4 ) have been confirmed.3 4 All five loci associate with RA in UK patients.5Functional variants of the Fc receptor-like 3 gene ( FCRL3 ), the solute carrier 22 member 4 gene ( SLC22A4 ) and the major histocompatibility complex, class II, transactivator gene ( MHC2TA ) associate with RA in some but not all populations.We have previously investigated polymorphisms in FCRL3 , MHC2TA and SLC22A4 in moderately sized UK studies and not detected evidence of association.6–8 Here we revisit these putative RA …" @default.
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• W2141551169 date "2009-07-15" @default.
• W2141551169 modified "2023-10-18" @default.
• W2141551169 title "A re-evaluation of three putative functional single nucleotide polymorphisms in rheumatoid arthritis" @default.
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• W2141551169 doi "https://doi.org/10.1136/ard.2008.103572" @default.
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