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• W2141557546 abstract "<h3>Background:</h3> Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression. <h3>Objective:</h3> To investigate the association of parity and secondary progression in women with MS. <h3>Methods:</h3> The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders. <h3>Results:</h3> Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression. <h3>Conclusion:</h3> We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed." @default.
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• W2141557546 date "2009-05-15" @default.
• W2141557546 modified "2023-10-17" @default.
• W2141557546 title "Parity and secondary progression in multiple sclerosis" @default.
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• W2141557546 doi "https://doi.org/10.1136/jnnp.2008.160911" @default.
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