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• W2141567354 startingPage "G835" @default.
• W2141567354 abstract "We studied the expression of endothelin-1 (ET-1) receptors (ET A and ET B ) and the effects of ET-1 on cholangiocyte secretion. The effects of ET-1 on cholangiocyte secretion were assessed in normal and bile duct-ligated (BDL) rats by measuring 1) basal and secretin-induced choleresis in vivo, 2) secretin receptor gene expression and cAMP levels in small and large cholangiocytes, and 3) luminal expansion in response to secretin in intrahepatic bile duct units (IBDU). ET A and ET B receptors were expressed by small and large cholangiocytes. ET-1 had no effect on basal bile flow or bicarbonate secretion in normal or BDL rats but decreased secretin-induced bicarbonate-rich choleresis in BDL rats. ET-1 decreased secretin receptor gene expression and secretin-stimulated cAMP synthesis in large cholangiocytes and secretin-induced luminal expansion in IBDU from normal or BDL rats. The inhibitory effects of ET-1 on secretin-induced cAMP synthesis and luminal duct expansion were blocked by specific inhibitors of the ET A (BQ-610) receptor. ET-1 inhibits secretin-induced ductal secretion by decreasing secretin receptor and cAMP synthesis, two important determinants of ductal secretion." @default.
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• W2141567354 date "1998-10-01" @default.
• W2141567354 modified "2023-10-15" @default.
• W2141567354 title "Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ET_Areceptors on large cholangiocytes" @default.
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• W2141567354 doi "https://doi.org/10.1152/ajpgi.1998.275.4.g835" @default.
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