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- W2141569445 abstract "Studies were done to test whether ethanol (ETOH) consumption alters resistance to mucosal and systemic infections by Salmonella typhimurium. S. typhimurium-immune and -nonimmune mice were fed 1 of 3 diets (an ETOH-containing liquid diet, an isocaloric liquid diet equal in volume to that of the ETOH-treated group, or laboratory chow) in a pair-feeding design and were infected orally or intravenously with S. typhimurium. The number of bacteria in spleen and liver and the effect of ETOH feeding and infection on the number of lymphoid cells in the gut-associated lymphoid tissues (GALT) were determined. ETOH feeding resulted in profound loss of GALT lymphoid cells and an increased number of Salmonella organisms in the intestines, liver, and spleen of infected nonimmune, but not of immune, mice. These data show that ETOH consumption in this model impairs host defense mechanisms that control mucosal infections and inhibits the mechanisms that control levels of bacteria in the central organs." @default.
- W2141569445 created "2016-06-24" @default.
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- W2141569445 date "2000-08-01" @default.
- W2141569445 modified "2023-09-27" @default.
- W2141569445 title "Alcohol Consumption by C57BL/6 Mice Is Associated with Depletion of Lymphoid Cells from the Gut‐Associated Lymphoid Tissues and Altered Resistance to Oral Infections with<i>Salmonella typhimurium</i>" @default.
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- W2141569445 doi "https://doi.org/10.1086/315728" @default.
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