Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141608653> ?p ?o ?g. }
- W2141608653 endingPage "658" @default.
- W2141608653 startingPage "641" @default.
- W2141608653 abstract "In an XX female, one of the two X chromosomes has been inactivated during early embryonic life to achieve a compensation of X-linked gene products between males and females, leaving only one allele of X-linked genes functional. There are some X-linked genes escaping the X-inactivation, i.e., being expressed from both alleles. Escape from X-inactivation varies at different levels; some genes have both alleles active in some women but only one allele active in others, whereas some other genes have both alleles active in neoplastic tissue but only one allele active normally. The X-inactivation may be considered functionally equivalent to a loss of heterozygosity (LOH) for some genes, whereas escape from X-inactivation may be equivalent to functional gene amplification for others. The physiological LOH may make X-linked tumor suppressor genes lose their function more easily, compared with autosomal tumor suppressor genes, thus predisposing women to cancer formation more easily. Moreover, the human X chromosome contains many genes related to cancer or to sex and reproduction. All these properties of the X chromosome suggest that it may play more important roles than any autosomal chromosome in the development and progression of reproductive and urologic cancers." @default.
- W2141608653 created "2016-06-24" @default.
- W2141608653 creator A5014281092 @default.
- W2141608653 creator A5042547707 @default.
- W2141608653 creator A5052845165 @default.
- W2141608653 creator A5062112339 @default.
- W2141608653 creator A5084666411 @default.
- W2141608653 date "2003-01-01" @default.
- W2141608653 modified "2023-09-26" @default.
- W2141608653 title "Novel Perspective: Focusing on the X Chromosome in Reproductive Cancers" @default.
- W2141608653 cites W12335643 @default.
- W2141608653 cites W1484293540 @default.
- W2141608653 cites W1486428894 @default.
- W2141608653 cites W149094837 @default.
- W2141608653 cites W1495111481 @default.
- W2141608653 cites W1496017988 @default.
- W2141608653 cites W1499944371 @default.
- W2141608653 cites W1501791679 @default.
- W2141608653 cites W1526580148 @default.
- W2141608653 cites W1532929086 @default.
- W2141608653 cites W1554130371 @default.
- W2141608653 cites W1577733427 @default.
- W2141608653 cites W1580875936 @default.
- W2141608653 cites W1607679412 @default.
- W2141608653 cites W168276155 @default.
- W2141608653 cites W1799177196 @default.
- W2141608653 cites W1927090780 @default.
- W2141608653 cites W1965612162 @default.
- W2141608653 cites W1966343726 @default.
- W2141608653 cites W1966501744 @default.
- W2141608653 cites W1966566133 @default.
- W2141608653 cites W1966726505 @default.
- W2141608653 cites W1966981147 @default.
- W2141608653 cites W1968317171 @default.
- W2141608653 cites W1969350240 @default.
- W2141608653 cites W1970671254 @default.
- W2141608653 cites W1970905211 @default.
- W2141608653 cites W1970961957 @default.
- W2141608653 cites W1971784972 @default.
- W2141608653 cites W1971916082 @default.
- W2141608653 cites W1972462861 @default.
- W2141608653 cites W1972684853 @default.
- W2141608653 cites W1972993755 @default.
- W2141608653 cites W1973708637 @default.
- W2141608653 cites W1974011033 @default.
- W2141608653 cites W1974395156 @default.
- W2141608653 cites W1975157608 @default.
- W2141608653 cites W1975341584 @default.
- W2141608653 cites W1976263259 @default.
- W2141608653 cites W1978675923 @default.
- W2141608653 cites W1978678628 @default.
- W2141608653 cites W1978861644 @default.
- W2141608653 cites W1981584846 @default.
- W2141608653 cites W1983865431 @default.
- W2141608653 cites W1983911931 @default.
- W2141608653 cites W1984323152 @default.
- W2141608653 cites W1984955367 @default.
- W2141608653 cites W1985973582 @default.
- W2141608653 cites W1986521259 @default.
- W2141608653 cites W1986612792 @default.
- W2141608653 cites W1987473563 @default.
- W2141608653 cites W1987726574 @default.
- W2141608653 cites W1988471794 @default.
- W2141608653 cites W1989628488 @default.
- W2141608653 cites W1990781573 @default.
- W2141608653 cites W1991257124 @default.
- W2141608653 cites W1992168356 @default.
- W2141608653 cites W1992675962 @default.
- W2141608653 cites W1992770735 @default.
- W2141608653 cites W1996309079 @default.
- W2141608653 cites W1996635873 @default.
- W2141608653 cites W1997315176 @default.
- W2141608653 cites W1997878837 @default.
- W2141608653 cites W1998408781 @default.
- W2141608653 cites W1998560981 @default.
- W2141608653 cites W2000130466 @default.
- W2141608653 cites W2000438090 @default.
- W2141608653 cites W2000708928 @default.
- W2141608653 cites W2001230855 @default.
- W2141608653 cites W2002206910 @default.
- W2141608653 cites W2002996110 @default.
- W2141608653 cites W2003432188 @default.
- W2141608653 cites W2003845408 @default.
- W2141608653 cites W2003872845 @default.
- W2141608653 cites W2004854776 @default.
- W2141608653 cites W2005482320 @default.
- W2141608653 cites W2006917721 @default.
- W2141608653 cites W2008211165 @default.
- W2141608653 cites W2008292129 @default.
- W2141608653 cites W2009297613 @default.
- W2141608653 cites W2009590659 @default.
- W2141608653 cites W2011139554 @default.
- W2141608653 cites W2012594643 @default.
- W2141608653 cites W2014106839 @default.
- W2141608653 cites W2015108113 @default.
- W2141608653 cites W2016298576 @default.
- W2141608653 cites W2017546997 @default.
- W2141608653 cites W2017702964 @default.