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- W2141610024 abstract "Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an antitumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This review focuses on the immune response and immune suppression in EOC. The immunological roles of chemotherapy and surgery in EOC are also described. Finally, we detail pilot data supporting the efficiency of immunotherapy in the treatment of EOC and the emerging concept that immunomodulation aimed at counteracting the immunosuppressive microenvironment must be associated with immunotherapy strategies." @default.
- W2141610024 created "2016-06-24" @default.
- W2141610024 creator A5006716940 @default.
- W2141610024 creator A5028330136 @default.
- W2141610024 creator A5030980738 @default.
- W2141610024 creator A5034482652 @default.
- W2141610024 creator A5041061170 @default.
- W2141610024 creator A5052014340 @default.
- W2141610024 creator A5052722880 @default.
- W2141610024 creator A5075951294 @default.
- W2141610024 creator A5083897536 @default.
- W2141610024 date "2013-06-13" @default.
- W2141610024 modified "2023-10-18" @default.
- W2141610024 title "Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer" @default.
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