FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141610267> ?p ?o ?g. }

• W2141610267 endingPage "526" @default.
• W2141610267 startingPage "519" @default.
• W2141610267 abstract "Aims In patients recovering from acute coronary syndromes (ACS) the role of oral anticoagulation (and its intensity) in addition to aspirin remains controversial. We conducted a specific meta-analysis of randomized trials comparing aspirin plus warfarin (A+W) with aspirin alone in such patients. Methods and results MEDLINE and Cochrane databases yielded 14 (of 148 potentially relevant) articles enrolling 25 307 patients. Follow-up ranged from 3 months to 5 years. Irrespective of International normalized ratio (INR), A+W did not significantly affect the risk of major adverse events (MAE: all cause death, non-fatal myocardial infarction, and non-fatal thrombo-embolic stroke) when compared with aspirin alone [OR 0.96 (0.90–1.03), P=0.30], but increased the risk of major bleeds (MB): OR 1.77 (1.47–2.13), P<0.00001. However, in studies with INR of 2–3, A+W was associated with a significant reduction of MAE [OR 0.73 (0.63–0.84), P<0.0001, number needed to treat to avoid one MAE=33], albeit at an increased risk of MB [OR 2.32 (1.63–3.29), P<0.00001; number needed to harm by causing one MB=100]. In both analyses, intracranial bleeding was not significantly increased by A+W when compared with aspirin alone. Conclusion For patients recovering from ACS, a combined strategy of A+W at INR values of 2–3 doubles the risk of MB, but is nonetheless superior to aspirin alone in preventing MAE. Whether this combined regimen is also superior to a ‘double’ anti-platelet strategy or to newer evolving treatments warrants further investigation." @default.
• W2141610267 created "2016-06-24" @default.
• W2141610267 creator A5031505042 @default.
• W2141610267 creator A5055084189 @default.
• W2141610267 creator A5073353856 @default.
• W2141610267 creator A5091851552 @default.
• W2141610267 date "2005-09-05" @default.
• W2141610267 modified "2023-10-04" @default.
• W2141610267 title "Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25 307 patients" @default.
• W2141610267 cites W1553345686 @default.
• W2141610267 cites W1954373103 @default.
• W2141610267 cites W1979363567 @default.
• W2141610267 cites W1990538732 @default.
• W2141610267 cites W1991549653 @default.
• W2141610267 cites W2000442546 @default.
• W2141610267 cites W2001688139 @default.
• W2141610267 cites W2012328700 @default.
• W2141610267 cites W2017836681 @default.
• W2141610267 cites W2024352468 @default.
• W2141610267 cites W2027151097 @default.
• W2141610267 cites W2029863503 @default.
• W2141610267 cites W2032335787 @default.
• W2141610267 cites W2040251457 @default.
• W2141610267 cites W2046051565 @default.
• W2141610267 cites W2047740656 @default.
• W2141610267 cites W2071535279 @default.
• W2141610267 cites W2077715397 @default.
• W2141610267 cites W2092123807 @default.
• W2141610267 cites W2119020141 @default.
• W2141610267 cites W2121366426 @default.
• W2141610267 cites W2125435699 @default.
• W2141610267 cites W2154923036 @default.
• W2141610267 cites W2157823046 @default.
• W2141610267 cites W2597867456 @default.
• W2141610267 cites W4237556338 @default.
• W2141610267 cites W42860337 @default.
• W2141610267 cites W2004276659 @default.
• W2141610267 doi "https://doi.org/10.1093/eurheartj/ehi485" @default.
• W2141610267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16143706" @default.
• W2141610267 hasPublicationYear "2005" @default.
• W2141610267 type Work @default.
• W2141610267 sameAs 2141610267 @default.
• W2141610267 citedByCount "267" @default.
• W2141610267 countsByYear W21416102672012 @default.
• W2141610267 countsByYear W21416102672013 @default.
• W2141610267 countsByYear W21416102672014 @default.
• W2141610267 countsByYear W21416102672015 @default.
• W2141610267 countsByYear W21416102672016 @default.
• W2141610267 countsByYear W21416102672017 @default.
• W2141610267 countsByYear W21416102672018 @default.
• W2141610267 countsByYear W21416102672019 @default.
• W2141610267 countsByYear W21416102672020 @default.
• W2141610267 countsByYear W21416102672021 @default.
• W2141610267 countsByYear W21416102672022 @default.
• W2141610267 countsByYear W21416102672023 @default.
• W2141610267 crossrefType "journal-article" @default.
• W2141610267 hasAuthorship W2141610267A5031505042 @default.
• W2141610267 hasAuthorship W2141610267A5055084189 @default.
• W2141610267 hasAuthorship W2141610267A5073353856 @default.
• W2141610267 hasAuthorship W2141610267A5091851552 @default.
• W2141610267 hasBestOaLocation W21416102671 @default.
• W2141610267 hasConcept C126322002 @default.
• W2141610267 hasConcept C127413603 @default.
• W2141610267 hasConcept C142454548 @default.
• W2141610267 hasConcept C168563851 @default.
• W2141610267 hasConcept C2776301958 @default.
• W2141610267 hasConcept C2777628954 @default.
• W2141610267 hasConcept C2777698277 @default.
• W2141610267 hasConcept C2779161974 @default.
• W2141610267 hasConcept C2780645631 @default.
• W2141610267 hasConcept C2781413609 @default.
• W2141610267 hasConcept C44249647 @default.
• W2141610267 hasConcept C500558357 @default.
• W2141610267 hasConcept C67774102 @default.
• W2141610267 hasConcept C71924100 @default.
• W2141610267 hasConcept C78519656 @default.
• W2141610267 hasConcept C82789193 @default.
• W2141610267 hasConceptScore W2141610267C126322002 @default.
• W2141610267 hasConceptScore W2141610267C127413603 @default.
• W2141610267 hasConceptScore W2141610267C142454548 @default.
• W2141610267 hasConceptScore W2141610267C168563851 @default.
• W2141610267 hasConceptScore W2141610267C2776301958 @default.
• W2141610267 hasConceptScore W2141610267C2777628954 @default.
• W2141610267 hasConceptScore W2141610267C2777698277 @default.
• W2141610267 hasConceptScore W2141610267C2779161974 @default.
• W2141610267 hasConceptScore W2141610267C2780645631 @default.
• W2141610267 hasConceptScore W2141610267C2781413609 @default.
• W2141610267 hasConceptScore W2141610267C44249647 @default.
• W2141610267 hasConceptScore W2141610267C500558357 @default.
• W2141610267 hasConceptScore W2141610267C67774102 @default.
• W2141610267 hasConceptScore W2141610267C71924100 @default.
• W2141610267 hasConceptScore W2141610267C78519656 @default.
• W2141610267 hasConceptScore W2141610267C82789193 @default.
• W2141610267 hasIssue "5" @default.
• W2141610267 hasLocation W21416102671 @default.
• W2141610267 hasLocation W21416102672 @default.
• W2141610267 hasOpenAccess W2141610267 @default.
• W2141610267 hasPrimaryLocation W21416102671 @default.

• next