FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141611982> ?p ?o ?g. }

• W2141611982 endingPage "917" @default.
• W2141611982 startingPage "869" @default.
• W2141611982 abstract "Intracranial self-stimulation (ICSS) is a behavioral procedure in which operant responding is maintained by pulses of electrical brain stimulation. In research to study abuse-related drug effects, ICSS relies on electrode placements that target the medial forebrain bundle at the level of the lateral hypothalamus, and experimental sessions manipulate frequency or amplitude of stimulation to engender a wide range of baseline response rates or response probabilities. Under these conditions, drug-induced increases in low rates/probabilities of responding maintained by low frequencies/amplitudes of stimulation are interpreted as an abuse-related effect. Conversely, drug-induced decreases in high rates/probabilities of responding maintained by high frequencies/amplitudes of stimulation can be interpreted as an abuse-limiting effect. Overall abuse potential can be inferred from the relative expression of abuse-related and abuse-limiting effects. The sensitivity and selectivity of ICSS to detect abuse potential of many classes of abused drugs is similar to the sensitivity and selectivity of drug self-administration procedures. Moreover, similar to progressive-ratio drug self-administration procedures, ICSS data can be used to rank the relative abuse potential of different drugs. Strengths of ICSS in comparison with drug self-administration include 1) potential for simultaneous evaluation of both abuse-related and abuse-limiting effects, 2) flexibility for use with various routes of drug administration or drug vehicles, 3) utility for studies in drug-naive subjects as well as in subjects with controlled levels of prior drug exposure, and 4) utility for studies of drug time course. Taken together, these considerations suggest that ICSS can make significant contributions to the practice of abuse potential testing." @default.
• W2141611982 created "2016-06-24" @default.
• W2141611982 creator A5005653699 @default.
• W2141611982 creator A5020814543 @default.
• W2141611982 date "2014-06-27" @default.
• W2141611982 modified "2023-10-06" @default.
• W2141611982 title "Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs" @default.
• W2141611982 cites W1498524645 @default.
• W2141611982 cites W1500701263 @default.
• W2141611982 cites W1513242235 @default.
• W2141611982 cites W1516172865 @default.
• W2141611982 cites W1543274849 @default.
• W2141611982 cites W1608852546 @default.
• W2141611982 cites W1678524661 @default.
• W2141611982 cites W175271008 @default.
• W2141611982 cites W1828753295 @default.
• W2141611982 cites W1900980019 @default.
• W2141611982 cites W1904408708 @default.
• W2141611982 cites W194496750 @default.
• W2141611982 cites W1957183612 @default.
• W2141611982 cites W1963521710 @default.
• W2141611982 cites W1963534883 @default.
• W2141611982 cites W1964082261 @default.
• W2141611982 cites W1964806845 @default.
• W2141611982 cites W1964918564 @default.
• W2141611982 cites W1965934941 @default.
• W2141611982 cites W1966351569 @default.
• W2141611982 cites W1966448429 @default.
• W2141611982 cites W1966462692 @default.
• W2141611982 cites W1967001305 @default.
• W2141611982 cites W1968148036 @default.
• W2141611982 cites W1968338376 @default.
• W2141611982 cites W1969542447 @default.
• W2141611982 cites W1970743983 @default.
• W2141611982 cites W1971280731 @default.
• W2141611982 cites W1971492254 @default.
• W2141611982 cites W1972095807 @default.
• W2141611982 cites W1972323820 @default.
• W2141611982 cites W1973330712 @default.
• W2141611982 cites W1973501710 @default.
• W2141611982 cites W1973667619 @default.
• W2141611982 cites W1975432588 @default.
• W2141611982 cites W1975579044 @default.
• W2141611982 cites W1976057792 @default.
• W2141611982 cites W1977079581 @default.
• W2141611982 cites W1977295715 @default.
• W2141611982 cites W1977899973 @default.
• W2141611982 cites W1978697276 @default.
• W2141611982 cites W1978812850 @default.
• W2141611982 cites W1979149627 @default.
• W2141611982 cites W1979744876 @default.
• W2141611982 cites W1980604756 @default.
• W2141611982 cites W1980915383 @default.
• W2141611982 cites W1980949824 @default.
• W2141611982 cites W1981336247 @default.
• W2141611982 cites W1982667365 @default.
• W2141611982 cites W1982683778 @default.
• W2141611982 cites W1983558573 @default.
• W2141611982 cites W1984259275 @default.
• W2141611982 cites W1985991621 @default.
• W2141611982 cites W1986602858 @default.
• W2141611982 cites W1986962942 @default.
• W2141611982 cites W1987336534 @default.
• W2141611982 cites W1987549408 @default.
• W2141611982 cites W1988659186 @default.
• W2141611982 cites W1988685132 @default.
• W2141611982 cites W1990001604 @default.
• W2141611982 cites W1991718370 @default.
• W2141611982 cites W1992088103 @default.
• W2141611982 cites W1993263160 @default.
• W2141611982 cites W1993524834 @default.
• W2141611982 cites W1993753770 @default.
• W2141611982 cites W1994428722 @default.
• W2141611982 cites W1994725667 @default.
• W2141611982 cites W1994754229 @default.
• W2141611982 cites W1995311828 @default.
• W2141611982 cites W1995865756 @default.
• W2141611982 cites W1995972006 @default.
• W2141611982 cites W1996499810 @default.
• W2141611982 cites W1996637072 @default.
• W2141611982 cites W1996642206 @default.
• W2141611982 cites W1996777105 @default.
• W2141611982 cites W1997464690 @default.
• W2141611982 cites W1997872409 @default.
• W2141611982 cites W1998445654 @default.
• W2141611982 cites W1998777715 @default.
• W2141611982 cites W1999366244 @default.
• W2141611982 cites W1999719215 @default.
• W2141611982 cites W1999724503 @default.
• W2141611982 cites W1999928356 @default.
• W2141611982 cites W2000136302 @default.
• W2141611982 cites W2000429782 @default.
• W2141611982 cites W2001283697 @default.
• W2141611982 cites W2002199969 @default.
• W2141611982 cites W2002355116 @default.
• W2141611982 cites W2002394101 @default.
• W2141611982 cites W2004030834 @default.
• W2141611982 cites W2004109806 @default.

• next