FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141648318> ?p ?o ?g. }

• W2141648318 endingPage "5030" @default.
• W2141648318 startingPage "5020" @default.
• W2141648318 abstract "In conjugating Tetrahymena thermophila, massive DNA elimination occurs upon the development of the new somatic genome from the germ line genome. Small, ∼28-nucleotide scan RNAs (scnRNAs) and Twi1p, an Argonaute family member, mediate H3K27me3 and H3K9me3 histone H3 modifications, which lead to heterochromatin formation and the excision of the heterochromatinized germ line-limited sequences. In our search for new factors involved in developmental DNA rearrangement, we identified two Twi1p-interacting proteins, Wag1p and CnjBp. Both proteins contain GW (glycine and tryptophan) repeats, which are characteristic of several Argonaute-interacting proteins in other organisms. Wag1p and CnjBp colocalize with Twi1p in the parental macronucleus early in conjugation and in the new developing macronucleus during later developmental stages. Around the time DNA elimination occurs, Wag1p forms multiple nuclear bodies in the developing macronuclei that do not colocalize with heterochromatic DNA elimination structures. Analyses of ΔWAG1, ΔCnjB, and double ΔWAG1 ΔCnjB knockout strains revealed that WAG1 and CnjB genes need to be deleted together to inhibit the downregulation of specific scnRNAs, the formation of DNA elimination structures, and DNA excision. Thus, Wag1p and CnjBp are two novel players with overlapping functions in RNA interference-mediated genome rearrangement in Tetrahymena." @default.
• W2141648318 created "2016-06-24" @default.
• W2141648318 creator A5008717335 @default.
• W2141648318 creator A5009869512 @default.
• W2141648318 creator A5015391242 @default.
• W2141648318 creator A5047487020 @default.
• W2141648318 creator A5069973846 @default.
• W2141648318 creator A5075720561 @default.
• W2141648318 creator A5087649710 @default.
• W2141648318 date "2009-09-01" @default.
• W2141648318 modified "2023-10-18" @default.
• W2141648318 title "Two GW Repeat Proteins Interact with <i>Tetrahymena thermophila</i> Argonaute and Promote Genome Rearrangement" @default.
• W2141648318 cites W1463780262 @default.
• W2141648318 cites W176521956 @default.
• W2141648318 cites W1965418757 @default.
• W2141648318 cites W1973763782 @default.
• W2141648318 cites W1979153554 @default.
• W2141648318 cites W1986328541 @default.
• W2141648318 cites W1988249075 @default.
• W2141648318 cites W1993180746 @default.
• W2141648318 cites W1993997766 @default.
• W2141648318 cites W1996832056 @default.
• W2141648318 cites W1997630514 @default.
• W2141648318 cites W2005866571 @default.
• W2141648318 cites W2017184218 @default.
• W2141648318 cites W2024334429 @default.
• W2141648318 cites W2027713539 @default.
• W2141648318 cites W2035782066 @default.
• W2141648318 cites W2040234712 @default.
• W2141648318 cites W2042836025 @default.
• W2141648318 cites W2051470352 @default.
• W2141648318 cites W2066611491 @default.
• W2141648318 cites W2070062799 @default.
• W2141648318 cites W2073403450 @default.
• W2141648318 cites W2082997857 @default.
• W2141648318 cites W2083367733 @default.
• W2141648318 cites W2085085592 @default.
• W2141648318 cites W2087746044 @default.
• W2141648318 cites W2090441795 @default.
• W2141648318 cites W2092592278 @default.
• W2141648318 cites W2094556974 @default.
• W2141648318 cites W2095724228 @default.
• W2141648318 cites W2107356537 @default.
• W2141648318 cites W2111791871 @default.
• W2141648318 cites W2116707781 @default.
• W2141648318 cites W2127043804 @default.
• W2141648318 cites W2137153000 @default.
• W2141648318 cites W2138535378 @default.
• W2141648318 cites W2141372590 @default.
• W2141648318 cites W2144950048 @default.
• W2141648318 cites W2145264494 @default.
• W2141648318 cites W2148954829 @default.
• W2141648318 cites W2152767935 @default.
• W2141648318 cites W2157551654 @default.
• W2141648318 cites W2161079626 @default.
• W2141648318 cites W2162100589 @default.
• W2141648318 cites W2166186329 @default.
• W2141648318 cites W2166404610 @default.
• W2141648318 cites W2167527994 @default.
• W2141648318 cites W2167852846 @default.
• W2141648318 cites W4233665000 @default.
• W2141648318 doi "https://doi.org/10.1128/mcb.00076-09" @default.
• W2141648318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2738283" @default.
• W2141648318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19596782" @default.
• W2141648318 hasPublicationYear "2009" @default.
• W2141648318 type Work @default.
• W2141648318 sameAs 2141648318 @default.
• W2141648318 citedByCount "43" @default.
• W2141648318 countsByYear W21416483182012 @default.
• W2141648318 countsByYear W21416483182013 @default.
• W2141648318 countsByYear W21416483182014 @default.
• W2141648318 countsByYear W21416483182015 @default.
• W2141648318 countsByYear W21416483182016 @default.
• W2141648318 countsByYear W21416483182017 @default.
• W2141648318 countsByYear W21416483182018 @default.
• W2141648318 countsByYear W21416483182019 @default.
• W2141648318 countsByYear W21416483182021 @default.
• W2141648318 countsByYear W21416483182022 @default.
• W2141648318 crossrefType "journal-article" @default.
• W2141648318 hasAuthorship W2141648318A5008717335 @default.
• W2141648318 hasAuthorship W2141648318A5009869512 @default.
• W2141648318 hasAuthorship W2141648318A5015391242 @default.
• W2141648318 hasAuthorship W2141648318A5047487020 @default.
• W2141648318 hasAuthorship W2141648318A5069973846 @default.
• W2141648318 hasAuthorship W2141648318A5075720561 @default.
• W2141648318 hasAuthorship W2141648318A5087649710 @default.
• W2141648318 hasBestOaLocation W21416483181 @default.
• W2141648318 hasConcept C103435993 @default.
• W2141648318 hasConcept C104317684 @default.
• W2141648318 hasConcept C153911025 @default.
• W2141648318 hasConcept C166703698 @default.
• W2141648318 hasConcept C201853390 @default.
• W2141648318 hasConcept C2777166614 @default.
• W2141648318 hasConcept C54355233 @default.
• W2141648318 hasConcept C552990157 @default.
• W2141648318 hasConcept C56683836 @default.
• W2141648318 hasConcept C67705224 @default.
• W2141648318 hasConcept C83640560 @default.

• next