FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141650231> ?p ?o ?g. }

• W2141650231 endingPage "6899" @default.
• W2141650231 startingPage "6892" @default.
• W2141650231 abstract "ABSTRACT Oxidation of malate to oxaloacetate in Escherichia coli can be catalyzed by two enzymes: the well-known NAD-dependent malate dehydrogenase (MDH; EC 1.1.1.37 ) and the membrane-associated malate:quinone-oxidoreductase (MQO; EC 1.1.99.16 ), encoded by the gene mqo (previously called yojH ). Expression of the mqo gene and, consequently, MQO activity are regulated by carbon and energy source for growth. In batch cultures, MQO activity was highest during exponential growth and decreased sharply after onset of the stationary phase. Experiments with the β-galactosidase reporter fused to the promoter of the mqo gene indicate that its transcription is regulated by the ArcA-ArcB two-component system. In contrast to earlier reports, MDH did not repress mqo expression. On the contrary, MQO and MDH are active at the same time in E. coli . For Corynebacterium glutamicum , it was found that MQO is the principal enzyme catalyzing the oxidation of malate to oxaloacetate. These observations justified a reinvestigation of the roles of MDH and MQO in the citric acid cycle of E. coli . In this organism, a defined deletion of the mdh gene led to severely decreased rates of growth on several substrates. Deletion of the mqo gene did not produce a distinguishable effect on the growth rate, nor did it affect the fitness of the organism in competition with the wild type. To investigate whether in an mqo mutant the conversion of malate to oxaloacetate could have been taken over by a bypass route via malic enzyme, phosphoenolpyruvate synthase, and phosphenolpyruvate carboxylase, deletion mutants of the malic enzyme genes sfcA and b2463 (coding for EC 1.1.1.38 and EC 1.1.1.40 , respectively) and of the phosphoenolpyruvate synthase (EC 2.7.9.2 ) gene pps were created. They were introduced separately or together with the deletion of mqo . These studies did not reveal a significant role for MQO in malate oxidation in wild-type E. coli . However, comparing growth of the mdh single mutant to that of the double mutant containing mdh and mqo deletions did indicate that MQO partly takes over the function of MDH in an mdh mutant." @default.
• W2141650231 created "2016-06-24" @default.
• W2141650231 creator A5038357639 @default.
• W2141650231 creator A5047527401 @default.
• W2141650231 creator A5080896728 @default.
• W2141650231 date "2000-12-15" @default.
• W2141650231 modified "2023-10-02" @default.
• W2141650231 title "Functions of the Membrane-Associated and Cytoplasmic Malate Dehydrogenases in the Citric Acid Cycle of <i>Escherichia coli</i>" @default.
• W2141650231 cites W106246676 @default.
• W2141650231 cites W107126037 @default.
• W2141650231 cites W1568735259 @default.
• W2141650231 cites W1577021598 @default.
• W2141650231 cites W1578261346 @default.
• W2141650231 cites W1765575636 @default.
• W2141650231 cites W1781531090 @default.
• W2141650231 cites W1810403705 @default.
• W2141650231 cites W1892013692 @default.
• W2141650231 cites W1921304878 @default.
• W2141650231 cites W1922319616 @default.
• W2141650231 cites W1960635497 @default.
• W2141650231 cites W1973537633 @default.
• W2141650231 cites W1977020556 @default.
• W2141650231 cites W2041715942 @default.
• W2141650231 cites W2042795207 @default.
• W2141650231 cites W2042814467 @default.
• W2141650231 cites W2060868140 @default.
• W2141650231 cites W2063953328 @default.
• W2141650231 cites W2085176594 @default.
• W2141650231 cites W2104488216 @default.
• W2141650231 cites W2125957234 @default.
• W2141650231 cites W2134153749 @default.
• W2141650231 cites W2161039496 @default.
• W2141650231 cites W230994631 @default.
• W2141650231 cites W2416472866 @default.
• W2141650231 cites W4232534952 @default.
• W2141650231 cites W4245245389 @default.
• W2141650231 cites W4296765338 @default.
• W2141650231 cites W54841302 @default.
• W2141650231 cites W60230853 @default.
• W2141650231 cites W80434006 @default.
• W2141650231 cites W80964436 @default.
• W2141650231 doi "https://doi.org/10.1128/jb.182.24.6892-6899.2000" @default.
• W2141650231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/94812" @default.
• W2141650231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11092847" @default.
• W2141650231 hasPublicationYear "2000" @default.
• W2141650231 type Work @default.
• W2141650231 sameAs 2141650231 @default.
• W2141650231 citedByCount "96" @default.
• W2141650231 countsByYear W21416502312012 @default.
• W2141650231 countsByYear W21416502312013 @default.
• W2141650231 countsByYear W21416502312014 @default.
• W2141650231 countsByYear W21416502312015 @default.
• W2141650231 countsByYear W21416502312016 @default.
• W2141650231 countsByYear W21416502312017 @default.
• W2141650231 countsByYear W21416502312018 @default.
• W2141650231 countsByYear W21416502312019 @default.
• W2141650231 countsByYear W21416502312020 @default.
• W2141650231 countsByYear W21416502312021 @default.
• W2141650231 countsByYear W21416502312022 @default.
• W2141650231 countsByYear W21416502312023 @default.
• W2141650231 crossrefType "journal-article" @default.
• W2141650231 hasAuthorship W2141650231A5038357639 @default.
• W2141650231 hasAuthorship W2141650231A5047527401 @default.
• W2141650231 hasAuthorship W2141650231A5080896728 @default.
• W2141650231 hasBestOaLocation W21416502312 @default.
• W2141650231 hasConcept C104317684 @default.
• W2141650231 hasConcept C111133373 @default.
• W2141650231 hasConcept C111341932 @default.
• W2141650231 hasConcept C132901563 @default.
• W2141650231 hasConcept C143937172 @default.
• W2141650231 hasConcept C153911025 @default.
• W2141650231 hasConcept C165135838 @default.
• W2141650231 hasConcept C165267168 @default.
• W2141650231 hasConcept C181199279 @default.
• W2141650231 hasConcept C2776260651 @default.
• W2141650231 hasConcept C2776317432 @default.
• W2141650231 hasConcept C2776336597 @default.
• W2141650231 hasConcept C2778957662 @default.
• W2141650231 hasConcept C2779969133 @default.
• W2141650231 hasConcept C547475151 @default.
• W2141650231 hasConcept C55493867 @default.
• W2141650231 hasConcept C75520062 @default.
• W2141650231 hasConcept C86803240 @default.
• W2141650231 hasConceptScore W2141650231C104317684 @default.
• W2141650231 hasConceptScore W2141650231C111133373 @default.
• W2141650231 hasConceptScore W2141650231C111341932 @default.
• W2141650231 hasConceptScore W2141650231C132901563 @default.
• W2141650231 hasConceptScore W2141650231C143937172 @default.
• W2141650231 hasConceptScore W2141650231C153911025 @default.
• W2141650231 hasConceptScore W2141650231C165135838 @default.
• W2141650231 hasConceptScore W2141650231C165267168 @default.
• W2141650231 hasConceptScore W2141650231C181199279 @default.
• W2141650231 hasConceptScore W2141650231C2776260651 @default.
• W2141650231 hasConceptScore W2141650231C2776317432 @default.
• W2141650231 hasConceptScore W2141650231C2776336597 @default.
• W2141650231 hasConceptScore W2141650231C2778957662 @default.
• W2141650231 hasConceptScore W2141650231C2779969133 @default.
• W2141650231 hasConceptScore W2141650231C547475151 @default.

• next