FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141659290> ?p ?o ?g. }

• W2141659290 abstract "In recent years inhibitors directed against the epidermal growth factor receptor (EGFR) have evolved as effective targeting cancer drugs. Characteristic papulopustular exanthemas, often described as acneiform rashes, are the most frequent adverse effect associated with this class of novel cancer drugs and develop in > 90% of patients. Notably, the rash may significantly compromise the patients' quality of life, thereby potentially leading to incompliance as well as dose reduction or even termination of the anti-EGFR therapy. Yet, an effective dermatologic management of cutaneous adverse effects can be achieved. Whereas various case reports, case series or expert opinions on the management of EGFR-inhibitor (EGFRI) induced rashes have been published, data on systematic management studies are sparse. Here, we present a retrospective, uncontrolled, comparative study in 49 patients on three established regimens for the management of EGFRI-associated rashes. Strikingly, patients' rash severity improved significantly over three weeks of treatment with topical mometason furoate cream, topical prednicarbate cream plus nadifloxacin cream, as well as topical prednicarbate cream plus nadifloxacin cream plus systemic isotretinoin. In summary our results demonstrate that EGFRI-associated rashes can be effectively managed by specific dermatologic interventions. Whereas mild to moderate rashes should be treated with basic measures in combination with topical glucocorticosteroids or combined regiments using glucocorticosteroids and antiseptics/antibiotics, more severe or therapy-resistant rashes are likely to respond with the addition of systemic retinoids." @default.
• W2141659290 created "2016-06-24" @default.
• W2141659290 creator A5017329335 @default.
• W2141659290 creator A5028687985 @default.
• W2141659290 creator A5039253396 @default.
• W2141659290 creator A5040321584 @default.
• W2141659290 creator A5055272825 @default.
• W2141659290 creator A5060729994 @default.
• W2141659290 creator A5065671121 @default.
• W2141659290 creator A5065805653 @default.
• W2141659290 creator A5070469545 @default.
• W2141659290 creator A5073722593 @default.
• W2141659290 creator A5073827670 @default.
• W2141659290 creator A5082151552 @default.
• W2141659290 date "2012-02-23" @default.
• W2141659290 modified "2023-09-27" @default.
• W2141659290 title "Management of EGFR-inhibitor associated rash: a retrospective study in 49 patients" @default.
• W2141659290 cites W1532983395 @default.
• W2141659290 cites W1552394333 @default.
• W2141659290 cites W1596514683 @default.
• W2141659290 cites W1965988047 @default.
• W2141659290 cites W1974406677 @default.
• W2141659290 cites W1975209104 @default.
• W2141659290 cites W1990967992 @default.
• W2141659290 cites W2014365289 @default.
• W2141659290 cites W2031520822 @default.
• W2141659290 cites W2031794924 @default.
• W2141659290 cites W2038254867 @default.
• W2141659290 cites W2046309480 @default.
• W2141659290 cites W2047416028 @default.
• W2141659290 cites W2048245888 @default.
• W2141659290 cites W2049484790 @default.
• W2141659290 cites W2069149537 @default.
• W2141659290 cites W2077144943 @default.
• W2141659290 cites W2078134764 @default.
• W2141659290 cites W2087911564 @default.
• W2141659290 cites W2100842180 @default.
• W2141659290 cites W2101100211 @default.
• W2141659290 cites W2105927767 @default.
• W2141659290 cites W2112610273 @default.
• W2141659290 cites W2113810254 @default.
• W2141659290 cites W2118011560 @default.
• W2141659290 cites W2126372889 @default.
• W2141659290 cites W2128542677 @default.
• W2141659290 cites W2133238086 @default.
• W2141659290 cites W2135594933 @default.
• W2141659290 cites W2138941169 @default.
• W2141659290 cites W2145863965 @default.
• W2141659290 cites W2148574319 @default.
• W2141659290 cites W2157824687 @default.
• W2141659290 cites W2255799293 @default.
• W2141659290 cites W277071610 @default.
• W2141659290 cites W62942737 @default.
• W2141659290 cites W78337089 @default.
• W2141659290 doi "https://doi.org/10.1186/2047-783x-17-4" @default.
• W2141659290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3351712" @default.
• W2141659290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22472354" @default.
• W2141659290 hasPublicationYear "2012" @default.
• W2141659290 type Work @default.
• W2141659290 sameAs 2141659290 @default.
• W2141659290 citedByCount "20" @default.
• W2141659290 countsByYear W21416592902013 @default.
• W2141659290 countsByYear W21416592902014 @default.
• W2141659290 countsByYear W21416592902015 @default.
• W2141659290 countsByYear W21416592902016 @default.
• W2141659290 countsByYear W21416592902017 @default.
• W2141659290 countsByYear W21416592902018 @default.
• W2141659290 countsByYear W21416592902019 @default.
• W2141659290 countsByYear W21416592902021 @default.
• W2141659290 countsByYear W21416592902022 @default.
• W2141659290 countsByYear W21416592902023 @default.
• W2141659290 crossrefType "journal-article" @default.
• W2141659290 hasAuthorship W2141659290A5017329335 @default.
• W2141659290 hasAuthorship W2141659290A5028687985 @default.
• W2141659290 hasAuthorship W2141659290A5039253396 @default.
• W2141659290 hasAuthorship W2141659290A5040321584 @default.
• W2141659290 hasAuthorship W2141659290A5055272825 @default.
• W2141659290 hasAuthorship W2141659290A5060729994 @default.
• W2141659290 hasAuthorship W2141659290A5065671121 @default.
• W2141659290 hasAuthorship W2141659290A5065805653 @default.
• W2141659290 hasAuthorship W2141659290A5070469545 @default.
• W2141659290 hasAuthorship W2141659290A5073722593 @default.
• W2141659290 hasAuthorship W2141659290A5073827670 @default.
• W2141659290 hasAuthorship W2141659290A5082151552 @default.
• W2141659290 hasBestOaLocation W21416592901 @default.
• W2141659290 hasConcept C121608353 @default.
• W2141659290 hasConcept C126322002 @default.
• W2141659290 hasConcept C16005928 @default.
• W2141659290 hasConcept C197934379 @default.
• W2141659290 hasConcept C2776285725 @default.
• W2141659290 hasConcept C2777035695 @default.
• W2141659290 hasConcept C2777506169 @default.
• W2141659290 hasConcept C2777673923 @default.
• W2141659290 hasConcept C2777789703 @default.
• W2141659290 hasConcept C2778081122 @default.
• W2141659290 hasConcept C2778570526 @default.
• W2141659290 hasConcept C2778847519 @default.
• W2141659290 hasConcept C2779438470 @default.
• W2141659290 hasConcept C71924100 @default.
• W2141659290 hasConcept C98274493 @default.

• next