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• W2141674392 abstract "Silva et al. show that CREB modulates allocation of fear memory to specific cells in the lateral amygdala. Reversibly inactivating a subset of CREB-expressing neurons disrupted memory for tone conditioning. Neurons with higher CREB levels were more excitable than their neighbors and showed larger synaptic efficacy changes following tone conditioning. The mechanisms that determine how information is allocated to specific regions and cells in the brain are important for memory capacity, storage and retrieval, but are poorly understood. We manipulated CREB in a subset of lateral amygdala neurons in mice with a modified herpes simplex virus (HSV) and reversibly inactivated transfected neurons with the Drosophila allatostatin G protein–coupled receptor (AlstR)/ligand system. We found that inactivation of the neurons transfected with HSV-CREB during training disrupted memory for tone conditioning, whereas inactivation of a similar proportion of transfected control neurons did not. Whole-cell recordings of fluorescently tagged transfected neurons revealed that neurons with higher CREB levels are more excitable than neighboring neurons and showed larger synaptic efficacy changes following conditioning. Our findings demonstrate that CREB modulates the allocation of fear memory to specific cells in lateral amygdala and suggest that neuronal excitability is important in this process." @default.
• W2141674392 created "2016-06-24" @default.
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• W2141674392 date "2009-09-27" @default.
• W2141674392 modified "2023-10-10" @default.
• W2141674392 title "CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala" @default.
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• W2141674392 doi "https://doi.org/10.1038/nn.2405" @default.
• W2141674392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2783698" @default.
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