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• W2141693417 endingPage "1169" @default.
• W2141693417 startingPage "1169" @default.
• W2141693417 abstract "<h3>Context</h3>Smaller hippocampal volumes are well established in posttraumatic stress disorder (PTSD), but the relatively few studies of amygdala volume in PTSD have produced equivocal results.<h3>Objective</h3>To assess a large cohort of recent military veterans with PTSD and trauma-exposed control subjects, with sufficient power to perform a definitive assessment of the effect of PTSD on volumetric changes in the amygdala and hippocampus and of the contribution of illness duration, trauma load, and depressive symptoms.<h3>Design</h3>Case-controlled design with structural magnetic resonance imaging and clinical diagnostic assessments. We controlled statistically for the important potential confounds of alcohol use, depression, and medication use.<h3>Setting</h3>Durham Veterans Affairs Medical Center, which is located in proximity to major military bases.<h3>Patients</h3>Ambulatory patients (n = 200) recruited from a registry of military service members and veterans serving after September 11, 2001, including a group with current PTSD (n = 99) and a trauma-exposed comparison group without PTSD (n = 101).<h3>Main Outcome Measure</h3>Amygdala and hippocampal volumes computed from automated segmentation of high-resolution structural 3-T magnetic resonance imaging.<h3>Results</h3>Smaller volume was demonstrated in the PTSD group compared with the non-PTSD group for the left amygdala (P = .002), right amygdala (P = .01), and left hippocampus (P = .02) but not for the right hippocampus (P = .25). Amygdala volumes were not associated with PTSD chronicity, trauma load, or severity of depressive symptoms.<h3>Conclusions</h3>These results provide clear evidence of an association between a smaller amygdala volume and PTSD. The lack of correlation between trauma load or illness chronicity and amygdala volume suggests that a smaller amygdala represents a vulnerability to developing PTSD or the lack of a dose-response relationship with amygdala volume. Our results may trigger a renewed impetus for investigating structural differences in the amygdala, its genetic determinants, its environmental modulators, and the possibility that it reflects an intrinsic vulnerability to PTSD." @default.
• W2141693417 created "2016-06-24" @default.
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• W2141693417 date "2012-11-01" @default.
• W2141693417 modified "2023-10-14" @default.
• W2141693417 title "Amygdala Volume Changes in Posttraumatic Stress Disorder in a Large Case-Controlled Veterans Group" @default.
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• W2141693417 doi "https://doi.org/10.1001/archgenpsychiatry.2012.50" @default.
• W2141693417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3647246" @default.
• W2141693417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23117638" @default.
• W2141693417 hasPublicationYear "2012" @default.
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