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- W2141749274 endingPage "101" @default.
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- W2141749274 abstract "To investigate the effect of catechin on apoptotic cell death in the lens epithelium of rats with cataract.Cataract was induced by intraperitoneal injection of 100 mg/kg N-methyl-N-nitrosourea (MNU) to ten day-old Sprague-Dawley rats. The neonatal rats were randomly divided into five groups (n=15 in each group): a control group, and four cataract-induction groups, treated with either 0, 50, 100, 200 mg/kg catechin. We performed slit-lamp biomicroscopic analysis, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, Western-blot for Bcl-2 and Bax, and immunohistochemistry for caspase-3.Apoptotic cell death in lens epithelial cells that increased following cataract formation in rats was suppressed by cathechin.Catechin inhibited cataract-induced apoptotic cell death in the lens epithelium and may prove useful for the prevention of cataract progression." @default.
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- W2141749274 date "2010-01-01" @default.
- W2141749274 modified "2023-10-02" @default.
- W2141749274 title "Protective Effect of Catechin on Apoptosis of the Lens Epithelium in Rats with N-methyl-N-nitrosourea-induced Cataracts" @default.
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- W2141749274 doi "https://doi.org/10.3341/kjo.2010.24.2.101" @default.
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