Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141799861> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2141799861 endingPage "439" @default.
- W2141799861 startingPage "429" @default.
- W2141799861 abstract "Inbred PVG rats infected with 100 Brugia pahangi infective larvae (L3) divide into rats that develop microfilaraemic infection (Mf+), and those that remain microfilaria negative (Mf-). All rats had high levels of specific IgG to adult worm and L3 extracts, however, after the onset of microfilaraemia, Mf+ rats had significantly higher levels of IgG to Mf extract. Mf+ rats recognized several antigenic components of each developmental extract that were not responded to by Mf- rats. In particular Mf+ rats recognized a triplet of proteins of 61-67 kD in microfilarial extract from day 74 post infection onwards. This indicated that these proteins were stage specific to Mf and Mf- rats had not been exposed to Mf rather than Mf absence being due to a protective antibody response. Analysis of the immunoglobulin isotype usage during infection revealed that each isotype was independent both in its period of induction and the developmental stage to which it responded. The predominant isotypes responding throughout infection were IgG1, IgG2a and IgM. Specific IgG2b and IgG2c were elevated early in infection but after the onset of microfilaraemia antibody of these subclasses was suppressed. The antigenic profiles recognized on immunoblots by IgG1, IgG2a and IgM were very similar." @default.
- W2141799861 created "2016-06-24" @default.
- W2141799861 creator A5004625330 @default.
- W2141799861 creator A5073469556 @default.
- W2141799861 date "1993-08-01" @default.
- W2141799861 modified "2023-09-24" @default.
- W2141799861 title "Stage and isotype specific immune responses in a rat model of filariasis" @default.
- W2141799861 cites W1562028730 @default.
- W2141799861 cites W1966719913 @default.
- W2141799861 cites W1984370570 @default.
- W2141799861 cites W1988124618 @default.
- W2141799861 cites W2012773720 @default.
- W2141799861 cites W2017508743 @default.
- W2141799861 cites W2023521376 @default.
- W2141799861 cites W2024212233 @default.
- W2141799861 cites W2046281538 @default.
- W2141799861 cites W2055816465 @default.
- W2141799861 cites W2079222099 @default.
- W2141799861 cites W2081116473 @default.
- W2141799861 cites W2087580730 @default.
- W2141799861 cites W209650906 @default.
- W2141799861 cites W2164464775 @default.
- W2141799861 cites W2321241086 @default.
- W2141799861 cites W2492570522 @default.
- W2141799861 cites W4249696305 @default.
- W2141799861 cites W4252835308 @default.
- W2141799861 cites W4320573425 @default.
- W2141799861 doi "https://doi.org/10.1111/j.1365-3024.1993.tb00628.x" @default.
- W2141799861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8233558" @default.
- W2141799861 hasPublicationYear "1993" @default.
- W2141799861 type Work @default.
- W2141799861 sameAs 2141799861 @default.
- W2141799861 citedByCount "5" @default.
- W2141799861 crossrefType "journal-article" @default.
- W2141799861 hasAuthorship W2141799861A5004625330 @default.
- W2141799861 hasAuthorship W2141799861A5073469556 @default.
- W2141799861 hasConcept C141105273 @default.
- W2141799861 hasConcept C147483822 @default.
- W2141799861 hasConcept C159654299 @default.
- W2141799861 hasConcept C165901193 @default.
- W2141799861 hasConcept C203014093 @default.
- W2141799861 hasConcept C2775848585 @default.
- W2141799861 hasConcept C2776158911 @default.
- W2141799861 hasConcept C2776548049 @default.
- W2141799861 hasConcept C2776573122 @default.
- W2141799861 hasConcept C2777629521 @default.
- W2141799861 hasConcept C2777991845 @default.
- W2141799861 hasConcept C2778672586 @default.
- W2141799861 hasConcept C2779359454 @default.
- W2141799861 hasConcept C2779726973 @default.
- W2141799861 hasConcept C2780898057 @default.
- W2141799861 hasConcept C542903549 @default.
- W2141799861 hasConcept C86803240 @default.
- W2141799861 hasConcept C8891405 @default.
- W2141799861 hasConceptScore W2141799861C141105273 @default.
- W2141799861 hasConceptScore W2141799861C147483822 @default.
- W2141799861 hasConceptScore W2141799861C159654299 @default.
- W2141799861 hasConceptScore W2141799861C165901193 @default.
- W2141799861 hasConceptScore W2141799861C203014093 @default.
- W2141799861 hasConceptScore W2141799861C2775848585 @default.
- W2141799861 hasConceptScore W2141799861C2776158911 @default.
- W2141799861 hasConceptScore W2141799861C2776548049 @default.
- W2141799861 hasConceptScore W2141799861C2776573122 @default.
- W2141799861 hasConceptScore W2141799861C2777629521 @default.
- W2141799861 hasConceptScore W2141799861C2777991845 @default.
- W2141799861 hasConceptScore W2141799861C2778672586 @default.
- W2141799861 hasConceptScore W2141799861C2779359454 @default.
- W2141799861 hasConceptScore W2141799861C2779726973 @default.
- W2141799861 hasConceptScore W2141799861C2780898057 @default.
- W2141799861 hasConceptScore W2141799861C542903549 @default.
- W2141799861 hasConceptScore W2141799861C86803240 @default.
- W2141799861 hasConceptScore W2141799861C8891405 @default.
- W2141799861 hasIssue "8" @default.
- W2141799861 hasLocation W21417998611 @default.
- W2141799861 hasLocation W21417998612 @default.
- W2141799861 hasOpenAccess W2141799861 @default.
- W2141799861 hasPrimaryLocation W21417998611 @default.
- W2141799861 hasRelatedWork W157111005 @default.
- W2141799861 hasRelatedWork W2124562194 @default.
- W2141799861 hasRelatedWork W2141799861 @default.
- W2141799861 hasRelatedWork W2164849709 @default.
- W2141799861 hasRelatedWork W2228733760 @default.
- W2141799861 hasRelatedWork W2325697673 @default.
- W2141799861 hasRelatedWork W2394628144 @default.
- W2141799861 hasRelatedWork W2410884042 @default.
- W2141799861 hasRelatedWork W2412669207 @default.
- W2141799861 hasRelatedWork W2418247903 @default.
- W2141799861 hasVolume "15" @default.
- W2141799861 isParatext "false" @default.
- W2141799861 isRetracted "false" @default.
- W2141799861 magId "2141799861" @default.
- W2141799861 workType "article" @default.