Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141807029> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2141807029 endingPage "114" @default.
- W2141807029 startingPage "114" @default.
- W2141807029 abstract "Increasing evidence suggests that epigenetic regulation is responsible for tumor initiation and progression in head and neck squamous cell carcinoma (HNSCC). Although the polycomb group protein enhancer zeste homolog 2 (EZH2) is upregulated and a key epigenetic modifier implicated in various cancers, its molecular mechanism in HNSCC remains unknown. Herein, we investigated the role of EZH2 in HNSCC progression and its clinical implication as an HNSCC risk predictor.A retrospective analysis was performed on 90 HNSCC patients who had curative surgery between 1999 and 2011. Patients with high and low EZH2 expression were compared by the various clinicopathological factors. Survival rates were estimated by the Kaplan–Meier method and log-rank test was used to determine significance. For functional in vitro analysis, migration/invasion assay and Western blotting were performed after EZH2 knockdown using siRNA. In addition, cell proliferation was measured to clarify the role of EZH2 on cisplatin chemotherapy.In patients with HNSCC, high EZH2 expression was correlated with advanced T stage and poor survival outcome. RNAi analysis revealed that EZH2 silencing increased E-cadherin expression while decreasing that of N-cadherin and Vimentin without altering Snail/Slug signaling, which led to decreased cell migration/invasion. EZH2 is also associated with tumor aggressiveness via regulating the epithelial-to-mesenchymal transition. Furthermore, we show that high EZH2 expression decreases sensitivity to cisplatin-based chemotherapy.Our results indicate that EZH2 may not be only a predictive and prognostic biomarker but also a potential personalized therapeutic target for the treatment of HNSCC." @default.
- W2141807029 created "2016-06-24" @default.
- W2141807029 creator A5011850447 @default.
- W2141807029 creator A5013221311 @default.
- W2141807029 creator A5020045253 @default.
- W2141807029 creator A5046485947 @default.
- W2141807029 creator A5046992933 @default.
- W2141807029 creator A5059295317 @default.
- W2141807029 creator A5069925055 @default.
- W2141807029 creator A5072366673 @default.
- W2141807029 creator A5081125103 @default.
- W2141807029 date "2010-03-01" @default.
- W2141807029 modified "2023-10-16" @default.
- W2141807029 title "194 DNA ploidy in relationship with EZH2 expression as markers of breast carcinomas" @default.
- W2141807029 doi "https://doi.org/10.1016/s1359-6349(10)70224-x" @default.
- W2141807029 hasPublicationYear "2010" @default.
- W2141807029 type Work @default.
- W2141807029 sameAs 2141807029 @default.
- W2141807029 citedByCount "1" @default.
- W2141807029 countsByYear W21418070292013 @default.
- W2141807029 crossrefType "journal-article" @default.
- W2141807029 hasAuthorship W2141807029A5011850447 @default.
- W2141807029 hasAuthorship W2141807029A5013221311 @default.
- W2141807029 hasAuthorship W2141807029A5020045253 @default.
- W2141807029 hasAuthorship W2141807029A5046485947 @default.
- W2141807029 hasAuthorship W2141807029A5046992933 @default.
- W2141807029 hasAuthorship W2141807029A5059295317 @default.
- W2141807029 hasAuthorship W2141807029A5069925055 @default.
- W2141807029 hasAuthorship W2141807029A5072366673 @default.
- W2141807029 hasAuthorship W2141807029A5081125103 @default.
- W2141807029 hasConcept C104317684 @default.
- W2141807029 hasConcept C119056186 @default.
- W2141807029 hasConcept C121608353 @default.
- W2141807029 hasConcept C126322002 @default.
- W2141807029 hasConcept C143998085 @default.
- W2141807029 hasConcept C173396325 @default.
- W2141807029 hasConcept C2776530083 @default.
- W2141807029 hasConcept C2776694085 @default.
- W2141807029 hasConcept C2776833033 @default.
- W2141807029 hasConcept C2778239845 @default.
- W2141807029 hasConcept C2779256057 @default.
- W2141807029 hasConcept C41091548 @default.
- W2141807029 hasConcept C50171091 @default.
- W2141807029 hasConcept C502942594 @default.
- W2141807029 hasConcept C54355233 @default.
- W2141807029 hasConcept C55493867 @default.
- W2141807029 hasConcept C71924100 @default.
- W2141807029 hasConcept C81885089 @default.
- W2141807029 hasConcept C86803240 @default.
- W2141807029 hasConceptScore W2141807029C104317684 @default.
- W2141807029 hasConceptScore W2141807029C119056186 @default.
- W2141807029 hasConceptScore W2141807029C121608353 @default.
- W2141807029 hasConceptScore W2141807029C126322002 @default.
- W2141807029 hasConceptScore W2141807029C143998085 @default.
- W2141807029 hasConceptScore W2141807029C173396325 @default.
- W2141807029 hasConceptScore W2141807029C2776530083 @default.
- W2141807029 hasConceptScore W2141807029C2776694085 @default.
- W2141807029 hasConceptScore W2141807029C2776833033 @default.
- W2141807029 hasConceptScore W2141807029C2778239845 @default.
- W2141807029 hasConceptScore W2141807029C2779256057 @default.
- W2141807029 hasConceptScore W2141807029C41091548 @default.
- W2141807029 hasConceptScore W2141807029C50171091 @default.
- W2141807029 hasConceptScore W2141807029C502942594 @default.
- W2141807029 hasConceptScore W2141807029C54355233 @default.
- W2141807029 hasConceptScore W2141807029C55493867 @default.
- W2141807029 hasConceptScore W2141807029C71924100 @default.
- W2141807029 hasConceptScore W2141807029C81885089 @default.
- W2141807029 hasConceptScore W2141807029C86803240 @default.
- W2141807029 hasIssue "3" @default.
- W2141807029 hasLocation W21418070291 @default.
- W2141807029 hasOpenAccess W2141807029 @default.
- W2141807029 hasPrimaryLocation W21418070291 @default.
- W2141807029 hasRelatedWork W2897635947 @default.
- W2141807029 hasRelatedWork W2978113027 @default.
- W2141807029 hasRelatedWork W3014576212 @default.
- W2141807029 hasRelatedWork W3015483624 @default.
- W2141807029 hasRelatedWork W3089756101 @default.
- W2141807029 hasRelatedWork W3094087408 @default.
- W2141807029 hasRelatedWork W3157541268 @default.
- W2141807029 hasRelatedWork W4214486964 @default.
- W2141807029 hasRelatedWork W4293173477 @default.
- W2141807029 hasRelatedWork W4319923850 @default.
- W2141807029 hasVolume "8" @default.
- W2141807029 isParatext "false" @default.
- W2141807029 isRetracted "false" @default.
- W2141807029 magId "2141807029" @default.
- W2141807029 workType "article" @default.