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• W2141819122 abstract "Abstract Background SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4 + T-cells. Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydrolyzes dNTPs and restricts HIV-1 infection in macrophages and resting CD4 + T-cells by decreasing the intracellular dNTP pool. However, the intracellular dNTP pool in DCs and its regulation by SAMHD1 remain unclear. SAMHD1 has been reported as a type I interferon (IFN)-inducible protein, but whether type I IFNs upregulate SAMHD1 expression in primary DCs and CD4 + T-lymphocytes is unknown. Results Here, we report that SAMHD1 significantly blocked single-cycle and replication-competent HIV-1 infection of DCs by decreasing the intracellular dNTP pool and thereby limiting the accumulation of HIV-1 late reverse transcription products. Type I IFN treatment did not upregulate endogenous SAMHD1 expression in primary DCs or CD4 + T-lymphocytes, but did in HEK 293T and HeLa cell lines. When SAMHD1 was over-expressed in these two cell lines to achieve higher levels than that in DCs, no HIV-1 restriction was observed despite partially reducing the intracellular dNTP pool. Conclusions Our results suggest that SAMHD1-mediated reduction of the intracellular dNTP pool in DCs is a common mechanism of HIV-1 restriction in myeloid cells. Endogenous expression of SAMHD1 in primary DCs or CD4 + T-lymphocytes is not upregulated by type I IFNs." @default.
• W2141819122 created "2016-06-24" @default.
• W2141819122 creator A5009488139 @default.
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• W2141819122 date "2012-12-01" @default.
• W2141819122 modified "2023-10-17" @default.
• W2141819122 title "SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+T-lymphocytes cannot be upregulated by interferons" @default.
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• W2141819122 doi "https://doi.org/10.1186/1742-4690-9-105" @default.
• W2141819122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3527137" @default.
• W2141819122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23231760" @default.
• W2141819122 hasPublicationYear "2012" @default.
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