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• W2141820798 abstract "Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by periodic provocative attacks of fever with peritonitis, pleuritis, arthritis, or eriseplemya. Tumor necrosis factor-α (TNF-α) plays an important role in the regulation of the immune response as a part of the cytokine network, including activation of macrophages and apoptosis. We investigated the possible association of TNF-α promoter −1031T/C and −308G/A polymorphisms in 86 FMF patients carrying M694 V homozygous mutation and 100 matched healthy controls both from Iranian Azeri Turks. Our data showed that patients with TNF-α −308 GG are more susceptible to the development of amyloidosis and arthritis ( P value <.05). These data also showed that the frequency of TNF-α −308 A allele is considerably low among patients with amyloidosis, and it may have protective role among them (odds ratio [OR] = 0.083, χ 2 = 5.46, P value = .003). Further evaluation of this polymorphism may be important and need further studies." @default.
• W2141820798 created "2016-06-24" @default.
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• W2141820798 date "2012-05-15" @default.
• W2141820798 modified "2023-10-16" @default.
• W2141820798 title "Tumor Necrosis Factor-α Gene Polymorphisms in FMF and Their Association With Amyloidosis" @default.
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• W2141820798 doi "https://doi.org/10.1177/1076029611432743" @default.
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