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- W2141902086 abstract "Herpes simplex virus type 1 (HSV-1) is an important human pathogen and a leading cause of infectious blindness in the developed world. HSV-1 exploits heparan sulfate proteoglycans (HSPG) for attachment to cells. While the significance of heparan sulphate (HS) moieties in HSV-1 infection is well established, the role of specific proteoglycan core proteins in the infection process remains poorly understood. The objective of this study was to assess the roles of syndecan-1 and syndecan-2 core proteins in HSV-1 infection, both of which are expressed by many HSV-1 target cell types. Our results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival. Furthermore, HSV-1 infection increases syndecan-1 and syndecan-2 protein synthesis and a resultant increase in cell surface expression of HS. Our observations suggest that changes in syndecan-1 and syndecan-2 expression levels may be related to active viral infection. Taken together, our findings provide new insights into HSPG functions during HSV-1 entry and spread." @default.
- W2141902086 created "2016-06-24" @default.
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- W2141902086 date "2010-12-09" @default.
- W2141902086 modified "2023-10-18" @default.
- W2141902086 title "Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection" @default.
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- W2141902086 doi "https://doi.org/10.1099/vir.0.027052-0" @default.
- W2141902086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3133699" @default.
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- W2141902086 hasPublicationYear "2010" @default.
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