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• W2141902291 startingPage "33" @default.
• W2141902291 abstract "In epithelial cells, the intracellular pathogen Salmonella typhimurium resides and replicates within a unique cytoplasmic organelle, the Salmonella-containing vacuole (SCV). In vitro studies have shown that the SCV is a dynamic organelle that selectively acquires lysosomal glycoproteins (Igps) without fusing directly with lyosomes. Here, we have investigated early events in SCV biogenesis using immunofluorescence microscopy and epitope-specific flow cytometry. We show that proteins specific to the early endocytic pathway, EEA1 and transferrin receptor (TR), are present on early SCVs. The association of these proteins with SCVs is transient, and both proteins are undetectable at later time points when Igp and vATPase are acquired. Analysis of the fraction of SCVs containing both TR and lamp-1 showed that TR is lost from SCVs as the Igp is acquired, and that these processes occur progressively and not as the result of a single fusion/fission event. These experiments reveal a novel mechanism of SCV biogenesis, involving previously undetected initial interactions with the early endocytic pathway followed by the sequential delivery of Igp. The pathway does not involve interactions with the late endosome/prelysosome and is distinct from traditional phagocytic and endocytic pathways. Our study indicates that intracellular S. typhimurium occupies a unique niche, branching away from the traditional endocytic pathway between the early and late endosomal compartments." @default.
• W2141902291 created "2016-06-24" @default.
• W2141902291 creator A5029576475 @default.
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• W2141902291 creator A5075336352 @default.
• W2141902291 creator A5084483302 @default.
• W2141902291 date "1999-07-01" @default.
• W2141902291 modified "2023-10-18" @default.
• W2141902291 title "Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway" @default.
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• W2141902291 doi "https://doi.org/10.1046/j.1462-5822.1999.00003.x" @default.
• W2141902291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11207539" @default.
• W2141902291 hasPublicationYear "1999" @default.
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