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- W2141926826 endingPage "496" @default.
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- W2141926826 abstract "The nerve growth factor protein (NGF) has been demonstrated to affect neuronal development and maintenance of the differentiated state in certain neurons of the peripheral and central nervous system (CNS) of mammals. In the CNS, NGF has sparing effects on cholinergic neurons of the rodent basal forebrain (BF) following lesions where it selectively induces choline acetyltransferase (ChAT). NGF also induces ChAT in the areas to which BF provides afferents. In aged rats, there is a reduction in the NGF-binding capacity of sympathetic ganglia. Here, we wish to report that there is a decrrease in the NGF-binding capacity of the hippocampus and basal forebrain of aged (26-month-old) rats as compared to 4-month-old controls but no change in NGF binding in cerebellum. In all instances, equilibrium binding dissociation constants did not differ significantly. Treatment of rats with acetyl-L-carnitine, reported to improve cognitive performance of aged rats, ameliorates these age-related deficits." @default.
- W2141926826 created "2016-06-24" @default.
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- W2141926826 date "1988-08-01" @default.
- W2141926826 modified "2023-09-25" @default.
- W2141926826 title "Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-l-carnitine" @default.
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- W2141926826 doi "https://doi.org/10.1002/jnr.490200413" @default.
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