FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141928265> ?p ?o ?g. }

• W2141928265 endingPage "317" @default.
• W2141928265 startingPage "309" @default.
• W2141928265 abstract "Rheumatic autoimmune diseases have been associated with accelerated atherosclerosis and various types of vasculopathies. Atherosclerosis is an inflammatory condition which starts as a “response to injury” favoring endothelial dysfunction which is associated with increased expression of adhesion molecules, pro-inflammatory cytokines, pro-thrombotic factors, oxidative stress upregulation and abnormal vascular tone modulation. Endothelial dysfunction in rheumatic autoimmune diseases involves innate immune responses, including macrophages and dendritic cells expression of scavenger and toll-like receptors for modified or native LDL as well as neutrophil and complement activation, and dysregulation of adaptive immune responses, including proliferation of autoreactive T-helper-1 lymphocytes and defective function of dendritic and regulatory T cells. Specific differences for endothelial function among different disorders include: a) increased amounts of pro-atherogenic hormones, decreased amounts of anti-atherogenic hormones and increased insulin resistance in rheumatoid arthritis; b) autoantibodies production in systemic lupus erythematosus and antiphospholipid syndrome; c) smooth muscle cells proliferation, destruction of internal elastic lamina, fibrosis and coagulation and fibrinolytic system dysfunction in systemic sclerosis. Several self-antigens (i.e. high density lipoproteins, heat shock proteins, β2-glycoprotein1) and self-molecules modified by oxidative events (i.e. low density lipoproteins and oxidized hemoglobin) have been identified as targets of autoimmune responses. Endothelial dysfunction leads to accelerated atherosclerosis in rheumatoid arthritis, systemic lupus erythematosus and spondyloarthropaties whereas obliterative vasculopathy is associated with systemic sclerosis. In this paper, we will briefly review the most relevant information upon endothelial dysfunction and inflammatory mechanisms in atherosclerosis and we will summarize the similarities and differences in vascular disease patterns underlying different rheumatic autoimmune diseases." @default.
• W2141928265 created "2016-06-24" @default.
• W2141928265 creator A5005600149 @default.
• W2141928265 creator A5036213927 @default.
• W2141928265 creator A5044850396 @default.
• W2141928265 creator A5045664956 @default.
• W2141928265 creator A5052016973 @default.
• W2141928265 creator A5059980960 @default.
• W2141928265 date "2012-10-01" @default.
• W2141928265 modified "2023-10-06" @default.
• W2141928265 title "Endothelial dysfunction in rheumatic autoimmune diseases" @default.
• W2141928265 cites W1535567348 @default.
• W2141928265 cites W1703151364 @default.
• W2141928265 cites W1810365440 @default.
• W2141928265 cites W1936786886 @default.
• W2141928265 cites W1964064254 @default.
• W2141928265 cites W1969111275 @default.
• W2141928265 cites W1970142855 @default.
• W2141928265 cites W1970629667 @default.
• W2141928265 cites W1980512218 @default.
• W2141928265 cites W1980948069 @default.
• W2141928265 cites W1990254338 @default.
• W2141928265 cites W1992082041 @default.
• W2141928265 cites W1992552859 @default.
• W2141928265 cites W1994955099 @default.
• W2141928265 cites W1995034631 @default.
• W2141928265 cites W1996866382 @default.
• W2141928265 cites W1998075515 @default.
• W2141928265 cites W2001182083 @default.
• W2141928265 cites W2002077734 @default.
• W2141928265 cites W2003013587 @default.
• W2141928265 cites W2006110725 @default.
• W2141928265 cites W2008960002 @default.
• W2141928265 cites W2018950002 @default.
• W2141928265 cites W2019190201 @default.
• W2141928265 cites W2021665051 @default.
• W2141928265 cites W2028416353 @default.
• W2141928265 cites W2028817828 @default.
• W2141928265 cites W2029070557 @default.
• W2141928265 cites W2033896075 @default.
• W2141928265 cites W2037332304 @default.
• W2141928265 cites W2038635079 @default.
• W2141928265 cites W2042692206 @default.
• W2141928265 cites W2042937684 @default.
• W2141928265 cites W2046140449 @default.
• W2141928265 cites W2048276401 @default.
• W2141928265 cites W2052474681 @default.
• W2141928265 cites W2054251943 @default.
• W2141928265 cites W2054284944 @default.
• W2141928265 cites W2054489990 @default.
• W2141928265 cites W2056713348 @default.
• W2141928265 cites W2058654367 @default.
• W2141928265 cites W2060168245 @default.
• W2141928265 cites W2063783489 @default.
• W2141928265 cites W2064693934 @default.
• W2141928265 cites W2069227990 @default.
• W2141928265 cites W2074744674 @default.
• W2141928265 cites W2089425800 @default.
• W2141928265 cites W2094629035 @default.
• W2141928265 cites W2096606701 @default.
• W2141928265 cites W2106237709 @default.
• W2141928265 cites W2109698138 @default.
• W2141928265 cites W2109863092 @default.
• W2141928265 cites W2115646199 @default.
• W2141928265 cites W2121955560 @default.
• W2141928265 cites W2123077388 @default.
• W2141928265 cites W2124472858 @default.
• W2141928265 cites W2125958260 @default.
• W2141928265 cites W2127620487 @default.
• W2141928265 cites W2129690247 @default.
• W2141928265 cites W2131342968 @default.
• W2141928265 cites W2133247340 @default.
• W2141928265 cites W2136347732 @default.
• W2141928265 cites W2137951377 @default.
• W2141928265 cites W2143330294 @default.
• W2141928265 cites W2144593277 @default.
• W2141928265 cites W2147779949 @default.
• W2141928265 cites W2148393857 @default.
• W2141928265 cites W2151131091 @default.
• W2141928265 cites W2151415561 @default.
• W2141928265 cites W2154402179 @default.
• W2141928265 cites W2155587118 @default.
• W2141928265 cites W2155783652 @default.
• W2141928265 cites W2157079253 @default.
• W2141928265 cites W2160097074 @default.
• W2141928265 cites W2162545043 @default.
• W2141928265 cites W2169552837 @default.
• W2141928265 cites W2170000390 @default.
• W2141928265 cites W2170569246 @default.
• W2141928265 cites W2170983723 @default.
• W2141928265 cites W2172232070 @default.
• W2141928265 cites W2173344597 @default.
• W2141928265 cites W2324841714 @default.
• W2141928265 cites W2434431068 @default.
• W2141928265 cites W3021852519 @default.
• W2141928265 cites W4252739453 @default.
• W2141928265 doi "https://doi.org/10.1016/j.atherosclerosis.2012.05.013" @default.
• W2141928265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22673743" @default.

• next