Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141935250> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2141935250 endingPage "108" @default.
- W2141935250 startingPage "101" @default.
- W2141935250 abstract "Niacin lowers levels of atherogenic apolipoprotein-B-containing lipoproteins, including lipoprotein(a), and raises levels of atheroprotective high-density lipoproteins. However, cutaneous flushing has been a major impediment to the clinical use of niacin.Extended-release niacin (niacin ER) is a once-daily prescription niacin formulated to limit flushing. An analysis of flushing events with niacin ER should facilitate its clinical use.The analysis pools previously unpublished data on flushing and related side effects from four randomized, double-blind studies of niacin ER, and also reviews long-term data on flushing from a 96-week open label, uncontrolled study.Among 333 patients treated with niacin ER (once daily at bedtime) for 3 to 6 months, 83% reported at least one flushing episode, compared to 18% of patients treated with placebo or gemfibrozil. Approximately 50% had ≤5 flushing events, and only 5% reported >20 flushing events. The majority (76%) of patients treated with niacin ER rated flushing events as mild to moderate in intensity; 6% of patients withdrew due to flushing. In an 8-week comparison of niacin ER once daily at bedtime with immediate-release niacin three times daily at equivalent total daily doses, the total number of flushing events was 76% lower in the niacin ER group.Niacin ER can help control flushing events while providing favorable effects on lipids and lipoproteins. The generalizability of this analysis may be limited by self-selection and motivation of research subjects, and further studies of flushing in the clinical practice setting are warranted." @default.
- W2141935250 created "2016-06-24" @default.
- W2141935250 creator A5008726377 @default.
- W2141935250 creator A5072193738 @default.
- W2141935250 date "2009-04-01" @default.
- W2141935250 modified "2023-09-27" @default.
- W2141935250 title "Flushing and other dermatologic adverse events associated with extended-release niacin therapy" @default.
- W2141935250 cites W1941984430 @default.
- W2141935250 cites W1980946271 @default.
- W2141935250 cites W1984146279 @default.
- W2141935250 cites W1990598691 @default.
- W2141935250 cites W1991444446 @default.
- W2141935250 cites W1992330736 @default.
- W2141935250 cites W2010047125 @default.
- W2141935250 cites W2015873233 @default.
- W2141935250 cites W2016950105 @default.
- W2141935250 cites W2019863077 @default.
- W2141935250 cites W2022809944 @default.
- W2141935250 cites W2027750202 @default.
- W2141935250 cites W2028737910 @default.
- W2141935250 cites W2046991199 @default.
- W2141935250 cites W2055318521 @default.
- W2141935250 cites W2070855777 @default.
- W2141935250 cites W2074571762 @default.
- W2141935250 cites W2078578691 @default.
- W2141935250 cites W2090809780 @default.
- W2141935250 cites W2103682415 @default.
- W2141935250 cites W2119065130 @default.
- W2141935250 cites W2155499238 @default.
- W2141935250 cites W2166038489 @default.
- W2141935250 cites W2169033201 @default.
- W2141935250 cites W4233804225 @default.
- W2141935250 cites W4241795379 @default.
- W2141935250 cites W4251300883 @default.
- W2141935250 doi "https://doi.org/10.1016/j.jacl.2009.02.003" @default.
- W2141935250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21291799" @default.
- W2141935250 hasPublicationYear "2009" @default.
- W2141935250 type Work @default.
- W2141935250 sameAs 2141935250 @default.
- W2141935250 citedByCount "11" @default.
- W2141935250 countsByYear W21419352502012 @default.
- W2141935250 countsByYear W21419352502015 @default.
- W2141935250 countsByYear W21419352502016 @default.
- W2141935250 countsByYear W21419352502017 @default.
- W2141935250 countsByYear W21419352502020 @default.
- W2141935250 crossrefType "journal-article" @default.
- W2141935250 hasAuthorship W2141935250A5008726377 @default.
- W2141935250 hasAuthorship W2141935250A5072193738 @default.
- W2141935250 hasConcept C126322002 @default.
- W2141935250 hasConcept C134018914 @default.
- W2141935250 hasConcept C197934379 @default.
- W2141935250 hasConcept C2778520758 @default.
- W2141935250 hasConcept C2778537899 @default.
- W2141935250 hasConcept C2780092750 @default.
- W2141935250 hasConcept C71924100 @default.
- W2141935250 hasConcept C90924648 @default.
- W2141935250 hasConcept C98274493 @default.
- W2141935250 hasConceptScore W2141935250C126322002 @default.
- W2141935250 hasConceptScore W2141935250C134018914 @default.
- W2141935250 hasConceptScore W2141935250C197934379 @default.
- W2141935250 hasConceptScore W2141935250C2778520758 @default.
- W2141935250 hasConceptScore W2141935250C2778537899 @default.
- W2141935250 hasConceptScore W2141935250C2780092750 @default.
- W2141935250 hasConceptScore W2141935250C71924100 @default.
- W2141935250 hasConceptScore W2141935250C90924648 @default.
- W2141935250 hasConceptScore W2141935250C98274493 @default.
- W2141935250 hasIssue "2" @default.
- W2141935250 hasLocation W21419352501 @default.
- W2141935250 hasLocation W21419352502 @default.
- W2141935250 hasOpenAccess W2141935250 @default.
- W2141935250 hasPrimaryLocation W21419352501 @default.
- W2141935250 hasRelatedWork W1966504330 @default.
- W2141935250 hasRelatedWork W1974041167 @default.
- W2141935250 hasRelatedWork W1979139803 @default.
- W2141935250 hasRelatedWork W2037631372 @default.
- W2141935250 hasRelatedWork W2043366273 @default.
- W2141935250 hasRelatedWork W2052542449 @default.
- W2141935250 hasRelatedWork W2057821332 @default.
- W2141935250 hasRelatedWork W2141935250 @default.
- W2141935250 hasRelatedWork W2146504312 @default.
- W2141935250 hasRelatedWork W2748952813 @default.
- W2141935250 hasVolume "3" @default.
- W2141935250 isParatext "false" @default.
- W2141935250 isRetracted "false" @default.
- W2141935250 magId "2141935250" @default.
- W2141935250 workType "article" @default.